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Peptide record

TPDB38597

Neurotoxin Toxicity standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB38597
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 20-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
TVIDVKCTSPKQCLPPCAKQ
Physicochemical Analysis
C92H159N25O28S3
RNEGHMFWY
CKP
2159.61
8.56
3
1
5
+2
5.50
-0.160
73.00
Mammalian: 7.2 hour Yeast: >20 hour E.coli: >10 hour
125
5.79
8
Residue Composition
number
1
A
0
R
0
N
1
D
3
C
0
E
2
Q
0
G
0
H
1
I
1
L
3
K
0
M
0
F
3
P
1
S
2
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 1 C: 3 E: 0 Q: 2 G: 0 H: 0 I: 1 L: 1 K: 3 M: 0 F: 0 P: 3 S: 1 T: 2 W: 0 Y: 0 V: 2
Chemical Descriptors
20
C92H159N25O28S3
2159.61
8.56
+2
5.50
-0.160
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Potent selective inhibitor of Kv1/KCNA voltage-gated potassium channels. {ECO:0000250}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Centruroides limbatus (Bark scorpion)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Potent selective inhibitor of Kv1/KCNA voltage-gated potassium channels..
Hongotoxin-5 (HgTX5) (Potassium channel toxin alpha-KTx 02)
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 02 subfamily
Evidence at protein level
Direct protein sequencing Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:9446567}.
Additional Detail Fields 7 fields
Direct protein sequencing Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 02 subfamily
Hongotoxin-5 (HgTX5) (Potassium channel toxin alpha-KTx 02)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:9446567}.
scorpion