Back to search

Peptide record

TPDB38584

Neurotoxin Toxicity standard
39 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB38584
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 39-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
TTINVKCTSPKQCLPPCKEIYGRHAGAKCINGKCHCSKI
Physicochemical Analysis
C179H301N55O51S6
DMFW
CK
4232.06
9.22
9
1
9
+6
9.72
-0.377
62.56
Mammalian: 7.2 hour Yeast: >20 hour E.coli: >10 hour
1865
44.07
15
Residue Composition
number
2
A
1
R
2
N
0
D
6
C
1
E
1
Q
3
G
2
H
4
I
1
L
6
K
0
M
0
F
3
P
2
S
3
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 2 R: 1 N: 2 D: 0 C: 6 E: 1 Q: 1 G: 3 H: 2 I: 4 L: 1 K: 6 M: 0 F: 0 P: 3 S: 2 T: 3 W: 0 Y: 1 V: 1
Chemical Descriptors
39
C179H301N55O51S6
4232.06
9.22
+6
9.72
-0.377
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Weakly blocks Kv1.3/KCNA3 voltage-gated potassium channels. {ECO:0000250|UniProtKB:P0C165}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Centruroides limpidus (Mexican scorpion)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Weakly blocks Kv1.3/KCNA3 voltage-gated potassium channels..
Potassium channel toxin alpha-KTx 2.18 (CllTx5)
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 02 subfamily
Evidence at protein level
Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:27889600}.
Additional Detail Fields 7 fields
Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 02 subfamily
Potassium channel toxin alpha-KTx 2.18 (CllTx5)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:27889600}.
scorpion