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Peptide record

TPDB38576

Neurotoxin Toxicity standard
99 amino acids
Basic Information
3D PDB MODEL
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TPDB38576
Neurotoxin Toxicity
Toxicity and safety peptides
Peptipedia
standard
No
A 99-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
TSQGTTPDKVQLEVNCISNLPNNEVEETDLLRELEMIEENLFGKELSFVPEENRNSRHKRCMGYDIECNERLHCCADLECVKTSGRWWYKKTYCRRKSG
Physicochemical Analysis
C495H786N146O161S9
E
11647.11
5.28
17
18
27
-3
39.36
-0.927
62.93
Mammalian: 7.2 hour Yeast: >20 hour E.coli: >10 hour
15845
136.04
32
Residue Composition
number
1
A
8
R
8
N
4
D
7
C
14
E
2
Q
5
G
2
H
3
I
9
L
7
K
2
M
2
F
3
P
6
S
6
T
2
W
3
Y
5
V
Amino Acid Distribution
A: 1 R: 8 N: 8 D: 4 C: 7 E: 14 Q: 2 G: 5 H: 2 I: 3 L: 9 K: 7 M: 2 F: 2 P: 3 S: 6 T: 6 W: 2 Y: 3 V: 5
Chemical Descriptors
99
C495H786N146O161S9
11647.11
5.28
-3
39.36
-0.927
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Inhibits voltage-gated sodium channels by binding to site 3. Insecticidal neurotoxin (By similarity). {ECO:0000250}.

Target

voltage-gated sodium channel (Nav) proton-gated sodium channel / ASIC

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Macrothele gigas (Japanese funnel web spider)
Neurotoxin
Inhibits voltage-gated sodium channels by binding to site 3. Insecticidal neurotoxin (By similarity)..
Mu-hexatoxin-Mg1c (Mu-HXTX-Mg1c) (Peptide toxin 6)
spider
Neurotoxin 14 (magi-1) family, 09 (magi-1) subfamily
Evidence at transcript level
Cleavage on pair of basic residues Disulfide bond Knottin Neurotoxin Secreted Signal Toxin
TISSUE SPECIFICITY: Expressed by the venom gland.
Additional Detail Fields 7 fields
Cleavage on pair of basic residues Disulfide bond Knottin Neurotoxin Secreted Signal Toxin
Neurotoxin
Evidence at transcript level
Neurotoxin 14 (magi-1) family, 09 (magi-1) subfamily
Mu-hexatoxin-Mg1c (Mu-HXTX-Mg1c) (Peptide toxin 6)
TISSUE SPECIFICITY: Expressed by the venom gland.
spider