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Peptide record

TPDB38558

Neurotoxin Toxicity standard
29 amino acids
Basic Information
3D PDB MODEL
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TPDB38558
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 29-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
TRCKGKGAPCRKTMYDCCSGSCGRRGKCG
Physicochemical Analysis
C118H205N45O37S7
NEQHILFWV
CG
3070.63
9.66
8
1
3
+7
6.70
-0.921
3.45
Mammalian: 7.2 hour Yeast: >20 hour E.coli: >10 hour
1865
60.74
11
Residue Composition
number
1
A
4
R
0
N
1
D
6
C
0
E
0
Q
6
G
0
H
0
I
0
L
4
K
1
M
0
F
1
P
2
S
2
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 1 R: 4 N: 0 D: 1 C: 6 E: 0 Q: 0 G: 6 H: 0 I: 0 L: 0 K: 4 M: 1 F: 0 P: 1 S: 2 T: 2 W: 0 Y: 1 V: 0
Chemical Descriptors
29
C118H205N45O37S7
3070.63
9.66
+7
6.70
-0.921
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels (Cav). This toxin preferentially blocks P/Q-type calcium channels (Cav2.1/CACNA1A) (IC(50)=0.60 nM) (PubMed:10938268, PubMed:1352986). Also shows an inhibition on Cav2.2/CACNA1A channels (IC(50)=7.0 nM) (PubMed:10938268). {ECO:0000269|PubMed:10938268, ECO:0000269|PubMed:1352986}.

Target

voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus magus (Magical cone)
Neurotoxin Presynaptic neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels (Cav). This toxin preferentially blocks P/Q-type calcium channels (Cav2.1/CACNA1A) (IC(50)=0.60 nM) (PubMed:10938268, PubMed:1352986).
Omega-conotoxin MVIIC (Omega-CgTxMVIIC) (SNX-230)
cone snail
Conotoxin O1 superfamily
Evidence at protein level
3D-structure Amidation Calcium channel impairing toxin Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Presynaptic neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:1352986}.
Additional Detail Fields 7 fields
3D-structure Amidation Calcium channel impairing toxin Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Presynaptic neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
Neurotoxin Presynaptic neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Evidence at protein level
Conotoxin O1 superfamily
Omega-conotoxin MVIIC (Omega-CgTxMVIIC) (SNX-230)
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:1352986}.
cone snail