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Peptide record

TPDB38557

Antifungal Antiparasitic Hemolysis Toxicity standard
29 amino acids
Basic Information
3D PDB MODEL
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TPDB38557
Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
Antifungipept dbAMP 3.0 i2APP Peptipedia APD_complete APD_hemolytic Hemolytic2
standard
No
A 29-aa standard natural multi-activity (Antifungal, Antiparasitic, Hemolysis, and other sources) peptide sequence curated from Antifungipept, dbAMP 3.0, i2APP, and other sources, with an available 3D structural model.
Sequence
TPCGESCVYIPCISGVIGCSCTDKVCYLN
Physicochemical Analysis
C127H203N31O42S6
ARQHMFW
C
3028.55
4.07
1
2
9
-1
1.66
0.679
83.79
Mammalian: 7.2 hour Yeast: >20 hour E.coli: >10 hour
3355
110.78
14
Residue Composition
number
0
A
0
R
1
N
1
D
6
C
1
E
0
Q
3
G
0
H
3
I
1
L
1
K
0
M
0
F
2
P
3
S
2
T
0
W
2
Y
3
V
Amino Acid Distribution
A: 0 R: 0 N: 1 D: 1 C: 6 E: 1 Q: 0 G: 3 H: 0 I: 3 L: 1 K: 1 M: 0 F: 0 P: 2 S: 3 T: 2 W: 0 Y: 2 V: 3
Chemical Descriptors
29
C127H203N31O42S6
3028.55
4.07
-1
1.66
0.679
Evidence Records 3 records
Evidence 1 Activity

Activity

HD50
Hemolysis
27.4
[Ref.20564013] HD50=27.4±1.2 µM against Human red blood cells .

Target

Human red blood cells

Source & Reference

APD_complete APD_hemolytic
DRAMP4
J Mol Biol. 1999 Dec 17 294(5):1327-1336.##Chembiochem. 2007 Jun 18 8(9):1001-1011.##Biopolymers. 2010 94(5):647-658.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.
Evidence 2 Activity

Activity

HD50
Toxicity
27.4
Hemolytic
Hemolytic_activity: [Ref.20564013] HD50=27.4±1.2 µM against Human red blood cells .

Target

erythrocytes

Source & Reference

NA
DRAMP
J Mol Biol. 1999 Dec 17 294(5):1327-1336.##Chembiochem. 2007 Jun 18 8(9):1001-1011.##Biopolymers. 2010 94(5):647-658.
Evidence 3 Hemolysis

Activity

27.4
HD50
[Ref.20564013] HD50=27.4±1.2 µM against Human red blood cells .
Hemolysis

Target

Human red blood cells

Source & Reference

APD_complete APD_hemolytic
J Mol Biol. 1999 Dec 17 294(5):1327-1336.##Chembiochem. 2007 Jun 18 8(9):1001-1011.##Biopolymers. 2010 94(5):647-658.
DRAMP4
APD_complete APD_hemolytic