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Peptide record

TPDB38510

Neurotoxin Toxicity standard
30 amino acids
Basic Information
3D PDB MODEL
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TPDB38510
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 30-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
TMCYSHTTTSRAILTNCGENSCYRKSRVHP
Physicochemical Analysis
C140H226N46O46S4
DQFW
T
3417.86
9.10
6
1
7
+3
6.08
-0.730
39.00
Mammalian: 7.2 hour Yeast: >20 hour E.coli: >10 hour
3105
90.85
16
Residue Composition
number
1
A
3
R
2
N
0
D
3
C
1
E
0
Q
1
G
2
H
1
I
1
L
1
K
1
M
0
F
1
P
4
S
5
T
0
W
2
Y
1
V
Amino Acid Distribution
A: 1 R: 3 N: 2 D: 0 C: 3 E: 1 Q: 0 G: 1 H: 2 I: 1 L: 1 K: 1 M: 1 F: 0 P: 1 S: 4 T: 5 W: 0 Y: 2 V: 1
Chemical Descriptors
30
C140H226N46O46S4
3417.86
9.10
+3
6.08
-0.730
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Inhibits acetylcholinesterase (By similarity). Has been described to inhibit both the slowly and the rapidly inactivating phases of potassium efflux (PubMed:1304870). {ECO:0000250|UniProtKB:P0C1Z0, ECO:0000269|PubMed:1304870}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Dendroaspis angusticeps (Eastern green mamba) (Naja angusticeps)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin
Inhibits acetylcholinesterase (By similarity). Has been described to inhibit both the slowly and the rapidly inactivating phases of potassium efflux (PubMed:1304870)..
Dendrotoxin A (DTX-A) (Fasciculin)
snake
Three-finger toxin family, Short-chain subfamily, Acn-esterase inhibitor sub-subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin
Evidence at protein level
Three-finger toxin family, Short-chain subfamily, Acn-esterase inhibitor sub-subfamily
Dendrotoxin A (DTX-A) (Fasciculin)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
snake