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Peptide record

TPDB38469

Neurotoxin Toxicity standard
37 amino acids
Basic Information
3D PDB MODEL
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TPDB38469
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 37-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
TIINVKCTSPKQCVPACKAAMGTVRAKCINGKCKCYI
Physicochemical Analysis
C167H291N49O46S7
DEHLFW
CK
3945.87
9.58
7
0
13
+7
5.32
0.219
76.49
Mammalian: 7.2 hour Yeast: >20 hour E.coli: >10 hour
1865
47.26
14
Residue Composition
number
4
A
1
R
2
N
0
D
6
C
0
E
1
Q
2
G
0
H
4
I
0
L
6
K
1
M
0
F
2
P
1
S
3
T
0
W
1
Y
3
V
Amino Acid Distribution
A: 4 R: 1 N: 2 D: 0 C: 6 E: 0 Q: 1 G: 2 H: 0 I: 4 L: 0 K: 6 M: 1 F: 0 P: 2 S: 1 T: 3 W: 0 Y: 1 V: 3
Chemical Descriptors
37
C167H291N49O46S7
3945.87
9.58
+7
5.32
0.219
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Reversibly blocks hKv1.1/KCNA1 (50% inhibition of current at 1 uM). Does not seem to be voltage-dependent. {ECO:0000269|PubMed:24512947}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Heteroctenus garridoi (Cuban scorpion) (Rhopalurus garridoi)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Reversibly blocks hKv1.1/KCNA1 (50% inhibition of current at 1 uM). Does not seem to be voltage-dependent..
Potassium channel toxin alpha-KTx 2.14
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 02 subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:24512947}.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 02 subfamily
Potassium channel toxin alpha-KTx 2.14
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:24512947}.
scorpion