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Peptide record

TPDB38464

Neurotoxin Toxicity standard
39 amino acids
Basic Information
3D PDB MODEL
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TPDB38464
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 39-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
TIINVKCTSPKQCLPPCKEIYGRHAGAKCMNGKCHCSKI
Physicochemical Analysis
C180H303N55O50S7
DFW
CK
4262.14
9.22
9
1
10
+6
9.35
-0.310
62.56
Mammalian: 7.2 hour Yeast: >20 hour E.coli: >10 hour
1865
43.76
14
Residue Composition
number
2
A
1
R
2
N
0
D
6
C
1
E
1
Q
3
G
2
H
4
I
1
L
6
K
1
M
0
F
3
P
2
S
2
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 2 R: 1 N: 2 D: 0 C: 6 E: 1 Q: 1 G: 3 H: 2 I: 4 L: 1 K: 6 M: 1 F: 0 P: 3 S: 2 T: 2 W: 0 Y: 1 V: 1
Chemical Descriptors
39
C180H303N55O50S7
4262.14
9.22
+6
9.35
-0.310
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Weakly blocks Kv1.3/KCNA3 voltage-gated potassium channels (Kd is estimated to be 69 nM). {ECO:0000269|PubMed:16026809}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Centruroides elegans (Bark scorpion)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Weakly blocks Kv1.3/KCNA3 voltage-gated potassium channels (Kd is estimated to be 69 nM)..
Potassium channel toxin alpha-KTx 2.12 (Toxin Ce5)
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 02 subfamily
Evidence at protein level
Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:16026809}.
Additional Detail Fields 7 fields
Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 02 subfamily
Potassium channel toxin alpha-KTx 2.12 (Toxin Ce5)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:16026809}.
scorpion