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Peptide record

TPDB38463

Neurotoxin Toxicity standard
39 amino acids
Basic Information
3D PDB MODEL
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TPDB38463
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 39-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
TIINVKCTSPKQCLLPCKQIYGPHAGAKCMNGKCHCSKI
Physicochemical Analysis
C180H303N53O49S7
RDEFW
CK
4218.13
9.22
8
0
11
+6
6.54
-0.097
72.56
Mammalian: 7.2 hour Yeast: >20 hour E.coli: >10 hour
1865
44.21
15
Residue Composition
number
2
A
0
R
2
N
0
D
6
C
0
E
2
Q
3
G
2
H
4
I
2
L
6
K
1
M
0
F
3
P
2
S
2
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 2 R: 0 N: 2 D: 0 C: 6 E: 0 Q: 2 G: 3 H: 2 I: 4 L: 2 K: 6 M: 1 F: 0 P: 3 S: 2 T: 2 W: 0 Y: 1 V: 1
Chemical Descriptors
39
C180H303N53O49S7
4218.13
9.22
+6
6.54
-0.097
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Blocks human voltage-gated potassium channels Kv1.1/KCNA1 (IC(50)=4.8 nM) and Kv1.2/KCNA2 (IC(50)=2.9 nM). {ECO:0000269|PubMed:26921461}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Centruroides tecomanus (Scorpion) (Centruroides limpidus tecomanus)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Blocks human voltage-gated potassium channels Kv1.1/KCNA1 (IC(50)=4.8 nM) and Kv1.2/KCNA2 (IC(50)=2.9 nM)..
Potassium channel toxin alpha-KTx 2.17 (Toxin II.12.8)
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 02 subfamily
Evidence at protein level
Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:26921461}.
Additional Detail Fields 7 fields
Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 02 subfamily
Potassium channel toxin alpha-KTx 2.17 (Toxin II.12.8)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:26921461}.
scorpion