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Peptide record

TPDB38461

Neurotoxin Toxicity standard
39 amino acids
Basic Information
3D PDB MODEL
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TPDB38461
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 39-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
TIINVKCTSPKQCLLPCKEIYGIHAGAKCMNGKCKCYKI
Physicochemical Analysis
C187H315N51O50S7
RDFW
K
4302.29
9.17
8
1
13
+6
6.18
0.028
82.56
Mammalian: 7.2 hour Yeast: >20 hour E.coli: >10 hour
3355
77.98
14
Residue Composition
number
2
A
0
R
2
N
0
D
6
C
1
E
1
Q
3
G
1
H
5
I
2
L
7
K
1
M
0
F
2
P
1
S
2
T
0
W
2
Y
1
V
Amino Acid Distribution
A: 2 R: 0 N: 2 D: 0 C: 6 E: 1 Q: 1 G: 3 H: 1 I: 5 L: 2 K: 7 M: 1 F: 0 P: 2 S: 1 T: 2 W: 0 Y: 2 V: 1
Chemical Descriptors
39
C187H315N51O50S7
4302.29
9.17
+6
6.18
0.028
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Blocks Kv1.3/KCNA3 voltage-gated potassium channels of human T-lymphocytes (Kd=0.98 nM). {ECO:0000269|PubMed:16026809}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Centruroides elegans (Bark scorpion)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Blocks Kv1.3/KCNA3 voltage-gated potassium channels of human T-lymphocytes (Kd=0.98 nM)..
Potassium channel toxin alpha-KTx 2.11 (Toxin Ce4)
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 02 subfamily
Evidence at protein level
Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:16026809}.
Additional Detail Fields 7 fields
Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 02 subfamily
Potassium channel toxin alpha-KTx 2.11 (Toxin Ce4)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:16026809}.
scorpion