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Peptide record

TPDB38458

Neurotoxin Toxicity standard
39 amino acids
Basic Information
3D PDB MODEL
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TPDB38458
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 39-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
TIINVKCTSPKQCLKPCKDLYGPHAGAKCMNGKCKCYNN
Physicochemical Analysis
C181H299N53O52S7
REFW
K
4274.11
9.17
8
1
10
+6
7.61
-0.538
52.56
Mammalian: 7.2 hour Yeast: >20 hour E.coli: >10 hour
3355
78.50
16
Residue Composition
number
2
A
0
R
4
N
1
D
6
C
0
E
1
Q
3
G
1
H
2
I
2
L
7
K
1
M
0
F
3
P
1
S
2
T
0
W
2
Y
1
V
Amino Acid Distribution
A: 2 R: 0 N: 4 D: 1 C: 6 E: 0 Q: 1 G: 3 H: 1 I: 2 L: 2 K: 7 M: 1 F: 0 P: 3 S: 1 T: 2 W: 0 Y: 2 V: 1
Chemical Descriptors
39
C181H299N53O52S7
4274.11
9.17
+6
7.61
-0.538
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Blocks Kv1.3/KCNA3 voltage-gated potassium channels of human T-lymphocytes (Kd=0.25 nM). {ECO:0000269|PubMed:16026809}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Centruroides elegans (Bark scorpion)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Blocks Kv1.3/KCNA3 voltage-gated potassium channels of human T-lymphocytes (Kd=0.25 nM)..
Potassium channel toxin alpha-KTx 2.9 (Toxin Ce2)
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 02 subfamily
Evidence at protein level
Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:16026809}.
Additional Detail Fields 7 fields
Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 02 subfamily
Potassium channel toxin alpha-KTx 2.9 (Toxin Ce2)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:16026809}.
scorpion