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Peptide record

TPDB38455

Neurotoxin Toxicity standard
38 amino acids
Basic Information
3D PDB MODEL
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TPDB38455
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 38-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
TIINEKCFATSQCWTPCKKAIGSLQSKCMNGKCKCYNG
Physicochemical Analysis
C177H288N50O53S7
RDHV
CK
4188.96
8.87
6
1
10
+5
4.25
-0.350
46.32
Mammalian: 7.2 hour Yeast: >20 hour E.coli: >10 hour
7365
175.82
18
Residue Composition
number
2
A
0
R
3
N
0
D
6
C
1
E
2
Q
3
G
0
H
3
I
1
L
6
K
1
M
1
F
1
P
3
S
3
T
1
W
1
Y
0
V
Amino Acid Distribution
A: 2 R: 0 N: 3 D: 0 C: 6 E: 1 Q: 2 G: 3 H: 0 I: 3 L: 1 K: 6 M: 1 F: 1 P: 1 S: 3 T: 3 W: 1 Y: 1 V: 0
Chemical Descriptors
38
C177H288N50O53S7
4188.96
8.87
+5
4.25
-0.350
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Blocks voltage-gated non-inactivating potassium channels (Kv) and unblocks inactivating potassium channels blocked by alpha-dendrotoxin in synaptosomes. It is not toxic to mice and crustaceans, but has a paralysing effect on crickets. {ECO:0000269|PubMed:8875778}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Centruroides noxius (Mexican scorpion)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Blocks voltage-gated non-inactivating potassium channels (Kv) and unblocks inactivating potassium channels blocked by alpha-dendrotoxin in synaptosomes. It is not toxic to mice and crustaceans, but has a paralysing effect on crickets..
Potassium channel toxin alpha-KTx 2.4 (Noxiustoxin-2) (NTx2)
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 02 subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:8875778}.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 02 subfamily
Potassium channel toxin alpha-KTx 2.4 (Noxiustoxin-2) (NTx2)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:8875778}.
scorpion