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Peptide record

TPDB38450

Neurotoxin Toxicity standard
36 amino acids
Basic Information
3D PDB MODEL
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TPDB38450
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 36-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
TGTSCISPKQCTEPCRAKGCKHGKCMNRKCHCMLCL
Physicochemical Analysis
C157H271N53O46S10
DFWYV
C
3957.81
8.75
9
1
6
+6
9.14
-0.439
35.28
Mammalian: 7.2 hour Yeast: >20 hour E.coli: >10 hour
500
12.63
15
Residue Composition
number
1
A
2
R
1
N
0
D
8
C
1
E
1
Q
3
G
2
H
1
I
2
L
5
K
2
M
0
F
2
P
2
S
3
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 2 N: 1 D: 0 C: 8 E: 1 Q: 1 G: 3 H: 2 I: 1 L: 2 K: 5 M: 2 F: 0 P: 2 S: 2 T: 3 W: 0 Y: 0 V: 0
Chemical Descriptors
36
C157H271N53O46S10
3957.81
8.75
+6
9.14
-0.439
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Blocks Shaker B channels expressed in Sf9 cells, with a dissociation constant of 52 nM. {ECO:0000269|PubMed:17030052}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Hoffmannihadrurus gertschi (Scorpion) (Hadrurus gertschi)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin
Blocks Shaker B channels expressed in Sf9 cells, with a dissociation constant of 52 nM..
Potassium channel toxin alpha-KTx 6.14 (HgeTx1)
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 06 subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:17030052}.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin
Evidence at protein level
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 06 subfamily
Potassium channel toxin alpha-KTx 6.14 (HgeTx1)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:17030052}.
scorpion