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Peptide record

TPDB38439

Neurotoxin Toxicity standard
65 amino acids
Basic Information
3D PDB MODEL
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TPDB38439
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 65-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
TICYNHLTRTSETTEICPDSWYFCYKISLADGNDVRIKRGCTFTCPELRPTGIYVYCCRRDKCNQ
Physicochemical Analysis
C329H509N93O100S8
M
CT
7623.70
7.84
10
7
19
+2
10.51
-0.494
58.46
Mammalian: 7.2 hour Yeast: >20 hour E.coli: >10 hour
13450
176.42
28
Residue Composition
number
1
A
6
R
3
N
4
D
8
C
3
E
1
Q
3
G
1
H
5
I
3
L
3
K
0
M
2
F
3
P
3
S
8
T
1
W
5
Y
2
V
Amino Acid Distribution
A: 1 R: 6 N: 3 D: 4 C: 8 E: 3 Q: 1 G: 3 H: 1 I: 5 L: 3 K: 3 M: 0 F: 2 P: 3 S: 3 T: 8 W: 1 Y: 5 V: 2
Chemical Descriptors
65
C329H509N93O100S8
7623.70
7.84
+2
10.51
-0.494
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Antagonist of muscle and neuronal nicotinic acetylcholine receptors (nAChR) with highest affinity for neuronal alpha-7/CHRNA7 nAChRs. {ECO:0000250|UniProtKB:A8N286}.

Target

nicotinic acetylcholine receptor (nAChR) acetylcholine receptor

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Naja kaouthia (Monocled cobra) (Naja siamensis)
Neurotoxin Postsynaptic neurotoxin G-protein coupled acetylcholine receptor impairing toxin G-protein coupled receptor impairing toxin
Antagonist of muscle and neuronal nicotinic acetylcholine receptors (nAChR) with highest affinity for neuronal alpha-7/CHRNA7 nAChRs..
Muscarinic toxin-like protein 3 (MTLP-3)
snake
Three-finger toxin family, Short-chain subfamily, Orphan group VIII (haditoxin) sub-subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond G-protein coupled acetylcholine receptor impairing toxin G-protein coupled receptor impairing toxin Neurotoxin Postsynaptic neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond G-protein coupled acetylcholine receptor impairing toxin G-protein coupled receptor impairing toxin Neurotoxin Postsynaptic neurotoxin Secreted Toxin
Neurotoxin Postsynaptic neurotoxin G-protein coupled acetylcholine receptor impairing toxin G-protein coupled receptor impairing toxin
Evidence at protein level
Three-finger toxin family, Short-chain subfamily, Orphan group VIII (haditoxin) sub-subfamily
Muscarinic toxin-like protein 3 (MTLP-3)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
snake