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Peptide record

TPDB38438

Neurotoxin Toxicity standard
26 amino acids
Basic Information
3D PDB MODEL
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TPDB38438
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 26-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
TICYNHLTIRSEVTEICIICDDDYYF
Physicochemical Analysis
C139H208N32O45S3
AQGKMPW
I
3143.55
3.84
2
5
11
-4
3.76
0.204
101.15
Mammalian: 7.2 hour Yeast: >20 hour E.coli: >10 hour
4595
146.17
11
Residue Composition
number
0
A
1
R
1
N
3
D
3
C
2
E
0
Q
0
G
1
H
5
I
1
L
0
K
0
M
1
F
0
P
1
S
3
T
0
W
3
Y
1
V
Amino Acid Distribution
A: 0 R: 1 N: 1 D: 3 C: 3 E: 2 Q: 0 G: 0 H: 1 I: 5 L: 1 K: 0 M: 0 F: 1 P: 0 S: 1 T: 3 W: 0 Y: 3 V: 1
Chemical Descriptors
26
C139H208N32O45S3
3143.55
3.84
-4
3.76
0.204
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Antagonist of muscle and neuronal nicotinic acetylcholine receptors (nAChR) with highest affinity for neuronal alpha-7/CHRNA7 nAChRs. {ECO:0000250|UniProtKB:A8N286}.

Target

nicotinic acetylcholine receptor (nAChR) acetylcholine receptor

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Naja naja (Indian cobra)
Neurotoxin Postsynaptic neurotoxin G-protein coupled acetylcholine receptor impairing toxin G-protein coupled receptor impairing toxin
Antagonist of muscle and neuronal nicotinic acetylcholine receptors (nAChR) with highest affinity for neuronal alpha-7/CHRNA7 nAChRs..
Muscarinic toxin-like protein 1 (MTLP-1) (Muscarinic toxin-like protein 2) (MTLP-2)
snake
Three-finger toxin family, Short-chain subfamily, Orphan group VIII (haditoxin) sub-subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond G-protein coupled acetylcholine receptor impairing toxin G-protein coupled receptor impairing toxin Neurotoxin Postsynaptic neurotoxin Reference proteome Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond G-protein coupled acetylcholine receptor impairing toxin G-protein coupled receptor impairing toxin Neurotoxin Postsynaptic neurotoxin Reference proteome Secreted Toxin
Neurotoxin Postsynaptic neurotoxin G-protein coupled acetylcholine receptor impairing toxin G-protein coupled receptor impairing toxin
Evidence at protein level
Three-finger toxin family, Short-chain subfamily, Orphan group VIII (haditoxin) sub-subfamily
Muscarinic toxin-like protein 1 (MTLP-1) (Muscarinic toxin-like protein 2) (MTLP-2)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
snake