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Peptide record

TPDB38436

Neurotoxin Toxicity standard
36 amino acids
Basic Information
3D PDB MODEL
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TPDB38436
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 36-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
TICTGADRPCAACCPCCPGTSCQGPESNGVVYCRNF
Physicochemical Analysis
C147H231N45O50S8
HLKMW
C
3685.20
5.91
2
2
8
-0
4.14
0.044
35.28
Mammalian: 7.2 hour Yeast: >20 hour E.coli: >10 hour
1990
54.00
17
Residue Composition
number
3
A
2
R
2
N
1
D
8
C
1
E
1
Q
4
G
0
H
1
I
0
L
0
K
0
M
1
F
4
P
2
S
3
T
0
W
1
Y
2
V
Amino Acid Distribution
A: 3 R: 2 N: 2 D: 1 C: 8 E: 1 Q: 1 G: 4 H: 0 I: 1 L: 0 K: 0 M: 0 F: 1 P: 4 S: 2 T: 3 W: 0 Y: 1 V: 2
Chemical Descriptors
36
C147H231N45O50S8
3685.20
5.91
-0
4.14
0.044
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: This excitatory toxin inhibits insect calcium-activated potassium (KCa) channels (Slo-type). {ECO:0000250|UniProtKB:P82228}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Hadronyche versuta (Blue mountains funnel-web spider) (Atrax versutus)
Neurotoxin Calcium-activated potassium channel impairing toxin Ion channel impairing toxin Potassium channel impairing toxin
This excitatory toxin inhibits insect calcium-activated potassium (KCa) channels (Slo-type)..
Lambda-hexatoxin-Hv1a (Lambda-HXTX-Hv1a) (Janus-atracotoxin-Hv1a) (Janus-AcTx-Hv1a) (Kappa-atracotoxin-Hv1a) (Kappa-AcTx-Hv1a) (Kappa-hexatoxin-Hv1a) (Kappa-HXTX-Hv1a)
spider
Neurotoxin 11 (kappa toxin) family
Evidence at protein level
Calcium-activated potassium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Potassium channel impairing toxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom gland.
Additional Detail Fields 7 fields
Calcium-activated potassium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Potassium channel impairing toxin Secreted Toxin
Neurotoxin Calcium-activated potassium channel impairing toxin Ion channel impairing toxin Potassium channel impairing toxin
Evidence at protein level
Neurotoxin 11 (kappa toxin) family
Lambda-hexatoxin-Hv1a (Lambda-HXTX-Hv1a) (Janus-atracotoxin-Hv1a) (Janus-AcTx-Hv1a) (Kappa-atracotoxin-Hv1a) (Kappa-AcTx-Hv1a) (Kappa-hexatoxin-Hv1a) (Kappa-HXTX-Hv1a)
TISSUE SPECIFICITY: Expressed by the venom gland.
spider