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Peptide record

TPDB38427

Neurotoxin Toxicity standard
34 amino acids
Basic Information
3D PDB MODEL
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TPDB38427
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 34-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
TGPQTTCQASTCEAGCKQIGKSMKSCQGDTCECA
Physicochemical Analysis
C132H223N41O53S7
RNHLFWYV
C
3456.89
6.09
3
3
5
-0
9.65
-0.544
20.29
Mammalian: 7.2 hour Yeast: >20 hour E.coli: >10 hour
375
10.85
18
Residue Composition
number
3
A
0
R
0
N
1
D
6
C
2
E
4
Q
4
G
0
H
1
I
0
L
3
K
1
M
0
F
1
P
3
S
5
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 3 R: 0 N: 0 D: 1 C: 6 E: 2 Q: 4 G: 4 H: 0 I: 1 L: 0 K: 3 M: 1 F: 0 P: 1 S: 3 T: 5 W: 0 Y: 0 V: 0
Chemical Descriptors
34
C132H223N41O53S7
3456.89
6.09
-0
9.65
-0.544
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Reversibly blocks Shaker B potassium channels. {ECO:0000269|PubMed:16705749}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Tityus discrepans (Venezuelan scorpion)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Reversibly blocks Shaker B potassium channels..
Potassium channel toxin alpha-KTx 18.2 (Toxin TdK2)
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 18 subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 18 subfamily
Potassium channel toxin alpha-KTx 18.2 (Toxin TdK2)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
scorpion