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Peptide record

TPDB38420

Neurotoxin Toxicity standard
37 amino acids
Basic Information
3D PDB MODEL
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TPDB38420
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 37-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
TFIDVDCTVSKECWAPCKAAFGVDRGKCMGKKCKCYV
Physicochemical Analysis
C177H281N47O50S7
NQHL
CK
4091.88
8.30
7
4
13
+3
6.09
0.003
50.00
Mammalian: 7.2 hour Yeast: >20 hour E.coli: >10 hour
7365
179.99
10
Residue Composition
number
3
A
1
R
0
N
3
D
6
C
1
E
0
Q
3
G
0
H
1
I
0
L
6
K
1
M
2
F
1
P
1
S
2
T
1
W
1
Y
4
V
Amino Acid Distribution
A: 3 R: 1 N: 0 D: 3 C: 6 E: 1 Q: 0 G: 3 H: 0 I: 1 L: 0 K: 6 M: 1 F: 2 P: 1 S: 1 T: 2 W: 1 Y: 1 V: 4
Chemical Descriptors
37
C177H281N47O50S7
4091.88
8.30
+3
6.09
0.003
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Reversibly blocks the high conductance calcium-activated potassium channels composed of only alpha subunits (KCa1.1/KCNMA1). Unreversibly blocks the high conductance calcium-activated potassium channels composed of alpha and beta1 subunits (KCNMA1 and KCNMB1). Unreversibly and weakly blocks the high conductance calcium-activated potassium channels composed of alpha and beta4 (KCNMA1 and KCNMB4). {ECO:0000269|PubMed:11576530}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Centruroides noxius (Mexican scorpion)
Neurotoxin Calcium-activated potassium channel impairing toxin Ion channel impairing toxin Potassium channel impairing toxin
Reversibly blocks the high conductance calcium-activated potassium channels composed of only alpha subunits (KCa1.1/KCNMA1). Unreversibly blocks the high conductance calcium-activated potassium channels composed of alpha and beta1 subunits (KCNMA1 and KCNMB1).
Potassium channel toxin alpha-KTx 1.11 (Slotoxin) (SloTx)
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 01 subfamily
Evidence at protein level
Calcium-activated potassium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:11576530}.
Additional Detail Fields 7 fields
Calcium-activated potassium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin
Neurotoxin Calcium-activated potassium channel impairing toxin Ion channel impairing toxin Potassium channel impairing toxin
Evidence at protein level
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 01 subfamily
Potassium channel toxin alpha-KTx 1.11 (Slotoxin) (SloTx)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:11576530}.
scorpion