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Peptide record

TPDB38389

Neurotoxin Toxicity standard
35 amino acids
Basic Information
3D PDB MODEL
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TPDB38389
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 35-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
TATCAGQDKPCQKHCDCCGPKGECVCEGPCICRQG
Physicochemical Analysis
C140H230N46O49S9
NLMFSWY
C
3630.19
6.66
5
4
4
-0
11.92
-0.494
25.14
Mammalian: 7.2 hour Yeast: >20 hour E.coli: >10 hour
500
13.77
14
Residue Composition
number
2
A
1
R
0
N
2
D
9
C
2
E
3
Q
5
G
1
H
1
I
0
L
3
K
0
M
0
F
3
P
0
S
2
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 2 R: 1 N: 0 D: 2 C: 9 E: 2 Q: 3 G: 5 H: 1 I: 1 L: 0 K: 3 M: 0 F: 0 P: 3 S: 0 T: 2 W: 0 Y: 0 V: 1
Chemical Descriptors
35
C140H230N46O49S9
3630.19
6.66
-0
11.92
-0.494
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Blocks voltage-gated sodium channels (Nav). {ECO:0000250}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Ctenus ornatus (Brazilian spider) (Oligoctenus ornatus)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Blocks voltage-gated sodium channels (Nav)..
U5-ctenitoxin-Co1a (U5-CNTX-Co1a) (Neurotoxin Oc F32-8)
spider
Neurotoxin 03 (Tx2) family, 06 subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|Ref.1}.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Neurotoxin 03 (Tx2) family, 06 subfamily
U5-ctenitoxin-Co1a (U5-CNTX-Co1a) (Neurotoxin Oc F32-8)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|Ref.1}.
spider