Back to search

Peptide record

TPDB38349

Neurotoxin Toxicity standard
31 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB38349
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 31-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
TCKQKGEGCSLDVECCSSSCKPGGPLFDFDC
Physicochemical Analysis
C132H207N35O48S6
ARNHIMWY
C
3244.66
4.20
3
5
5
-2
8.13
-0.290
34.52
Mammalian: 7.2 hour Yeast: >20 hour E.coli: >10 hour
375
11.56
12
Residue Composition
number
0
A
0
R
0
N
3
D
6
C
2
E
1
Q
4
G
0
H
0
I
2
L
3
K
0
M
2
F
2
P
4
S
1
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 3 C: 6 E: 2 Q: 1 G: 4 H: 0 I: 0 L: 2 K: 3 M: 0 F: 2 P: 2 S: 4 T: 1 W: 0 Y: 0 V: 1
Chemical Descriptors
31
C132H207N35O48S6
3244.66
4.20
-2
8.13
-0.290
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Gamma-conotoxins may act on voltage-gated non-specific cation pacemaker channels (HCN) (By similarity). Elicits toxic effects in the freshwater snail Pomacea paludosa after intramuscular injection, but it has no effect when injected intracerebrally into mice. {ECO:0000250}.

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus cancellatus (Cancellate cone) (Conus austini)
Neurotoxin Ion channel impairing toxin
Gamma-conotoxins may act on voltage-gated non-specific cation pacemaker channels (HCN) (By similarity). Elicits toxic effects in the freshwater snail Pomacea paludosa after intramuscular injection, but it has no effect when injected intracerebrally into mice..
Gamma-conotoxin-like As7a
cone snail
Conotoxin O1 superfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Gamma-carboxyglutamic acid Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom duct.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Gamma-carboxyglutamic acid Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin
Neurotoxin Ion channel impairing toxin
Evidence at protein level
Conotoxin O1 superfamily
Gamma-conotoxin-like As7a
TISSUE SPECIFICITY: Expressed by the venom duct.
cone snail