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Peptide record

TPDB38307

Neurotoxin Toxicity standard
29 amino acids
Basic Information
3D PDB MODEL
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TPDB38307
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 29-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
STRCQGRGASCRKTMYNCCSGSCNRGRCG
Physicochemical Analysis
C114H196N48O40S7
DEHILFPWV
C
3103.53
9.34
6
0
3
+6
4.53
-0.900
3.45
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
1865
60.09
16
Residue Composition
number
1
A
5
R
2
N
0
D
6
C
0
E
1
Q
5
G
0
H
0
I
0
L
1
K
1
M
0
F
0
P
4
S
2
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 1 R: 5 N: 2 D: 0 C: 6 E: 0 Q: 1 G: 5 H: 0 I: 0 L: 0 K: 1 M: 1 F: 0 P: 0 S: 4 T: 2 W: 0 Y: 1 V: 0
Chemical Descriptors
29
C114H196N48O40S7
3103.53
9.34
+6
4.53
-0.900
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels (Cav). This toxin blocks channels of the N-type as well as other types.

Target

voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus magus (Magical cone)
Neurotoxin Presynaptic neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels (Cav). This toxin blocks channels of the N-type as well as other types.
Omega-conotoxin MVIID (SNX-238)
cone snail
Conotoxin O1 superfamily
Evidence at protein level
Amidation Calcium channel impairing toxin Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Presynaptic neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom duct.
Additional Detail Fields 7 fields
Amidation Calcium channel impairing toxin Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Presynaptic neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
Neurotoxin Presynaptic neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Evidence at protein level
Conotoxin O1 superfamily
Omega-conotoxin MVIID (SNX-238)
TISSUE SPECIFICITY: Expressed by the venom duct.
cone snail