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Peptide record

TPDB38227

Neurotoxin Toxicity standard
39 amino acids
Basic Information
3D PDB MODEL
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TPDB38227
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 39-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
SPVCTPSGQPCQPNTQPCCNNAEEEQTINCNGNTVYRCA
Physicochemical Analysis
C165H260N52O63S6
DHLKMFW
NC
4172.55
3.96
1
3
6
-2
11.91
-0.846
30.00
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
1865
44.70
23
Residue Composition
number
2
A
1
R
6
N
0
D
6
C
3
E
4
Q
2
G
0
H
1
I
0
L
0
K
0
M
0
F
5
P
2
S
4
T
0
W
1
Y
2
V
Amino Acid Distribution
A: 2 R: 1 N: 6 D: 0 C: 6 E: 3 Q: 4 G: 2 H: 0 I: 1 L: 0 K: 0 M: 0 F: 0 P: 5 S: 2 T: 4 W: 0 Y: 1 V: 2
Chemical Descriptors
39
C165H260N52O63S6
4172.55
3.96
-2
11.91
-0.846
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Potent inhibitor of insect, but not mammalian, voltage-gated calcium channels (Cav). {ECO:0000250}.

Target

voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Missulena bradleyi (Eastern mouse spider)
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Potent inhibitor of insect, but not mammalian, voltage-gated calcium channels (Cav)..
Omega-actinopoditoxin-Mb1a (Omega-AOTX-Mb1a) (Omega-missulenatoxin-Mb1a) (Omega-MSTX-Mb1a)
spider
Neurotoxin 08 (Shiva) family, 02 (omega/kappa toxin) subfamily
Evidence at protein level
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|Ref.1, ECO:0000305}.
Additional Detail Fields 7 fields
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Evidence at protein level
Neurotoxin 08 (Shiva) family, 02 (omega/kappa toxin) subfamily
Omega-actinopoditoxin-Mb1a (Omega-AOTX-Mb1a) (Omega-missulenatoxin-Mb1a) (Omega-MSTX-Mb1a)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|Ref.1, ECO:0000305}.
spider