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Peptide record

TPDB38195

Neurotoxin Toxicity standard
37 amino acids
Basic Information
3D PDB MODEL
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TPDB38195
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 37-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
SPTCTGADRPCAACCPCCPGTSCKGPEPNGVSYCRND
Physicochemical Analysis
C145H230N46O53S8
QHILMFW
C
3722.18
5.97
3
3
5
-0
8.18
-0.481
15.95
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
1990
53.46
17
Residue Composition
number
3
A
2
R
2
N
2
D
8
C
1
E
0
Q
4
G
0
H
0
I
0
L
1
K
0
M
0
F
6
P
3
S
3
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 3 R: 2 N: 2 D: 2 C: 8 E: 1 Q: 0 G: 4 H: 0 I: 0 L: 0 K: 1 M: 0 F: 0 P: 6 S: 3 T: 3 W: 0 Y: 1 V: 1
Chemical Descriptors
37
C145H230N46O53S8
3722.18
5.97
-0
8.18
-0.481
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: This excitatory toxin inhibits insect calcium-activated potassium (KCa) channels (Slo-type). {ECO:0000250|UniProtKB:P82228}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Hadronyche formidabilis (Northern tree funnel-web spider) (Atrax formidabilis)
Neurotoxin Calcium-activated potassium channel impairing toxin Ion channel impairing toxin Potassium channel impairing toxin
This excitatory toxin inhibits insect calcium-activated potassium (KCa) channels (Slo-type)..
Lambda-hexatoxin-Hf1a (Lambda-HXTX-Hf1a) (Janus-atracotoxin-Hf1a) (Janus-AcTx-Hf1a) (Kappa-atracotoxin-Hf1a) (Kappa-AcTx-Hf1a) (Kappa-hexatoxin-Hf1a) (Kappa-HXTX-Hf1a)
spider
Neurotoxin 11 (kappa toxin) family
Evidence at protein level
Calcium-activated potassium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Potassium channel impairing toxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom gland.
Additional Detail Fields 7 fields
Calcium-activated potassium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Potassium channel impairing toxin Secreted Toxin
Neurotoxin Calcium-activated potassium channel impairing toxin Ion channel impairing toxin Potassium channel impairing toxin
Evidence at protein level
Neurotoxin 11 (kappa toxin) family
Lambda-hexatoxin-Hf1a (Lambda-HXTX-Hf1a) (Janus-atracotoxin-Hf1a) (Janus-AcTx-Hf1a) (Kappa-atracotoxin-Hf1a) (Kappa-AcTx-Hf1a) (Kappa-hexatoxin-Hf1a) (Kappa-HXTX-Hf1a)
TISSUE SPECIFICITY: Expressed by the venom gland.
spider