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Peptide record

TPDB38192

Neurotoxin Toxicity standard
37 amino acids
Basic Information
3D PDB MODEL
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TPDB38192
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 37-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
SPTCIPSGQPCPYNENCCSQSCTYKENENGNTVKRCD
Physicochemical Analysis
C162H253N49O62S6
AHLMFW
C
4071.44
4.65
3
4
4
-1
12.54
-1.141
18.38
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
3355
82.40
22
Residue Composition
number
0
A
1
R
5
N
1
D
6
C
3
E
2
Q
2
G
0
H
1
I
0
L
2
K
0
M
0
F
4
P
4
S
3
T
0
W
2
Y
1
V
Amino Acid Distribution
A: 0 R: 1 N: 5 D: 1 C: 6 E: 3 Q: 2 G: 2 H: 0 I: 1 L: 0 K: 2 M: 0 F: 0 P: 4 S: 4 T: 3 W: 0 Y: 2 V: 1
Chemical Descriptors
37
C162H253N49O62S6
4071.44
4.65
-1
12.54
-1.141
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Inhibits insect, but not mammalian, voltage-gated calcium channels (Cav). {ECO:0000250|UniProtKB:P56207}.

Target

voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Hadronyche versuta (Blue mountains funnel-web spider) (Atrax versutus)
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Inhibits insect, but not mammalian, voltage-gated calcium channels (Cav)..
Omega-hexatoxin-Hv1e (Omega-HXTX-Hv1e) (Omega-atracotoxin-Hv1e) (Omega-AcTx-Hv1e)
spider
Neurotoxin 08 (Shiva) family, 01 (omega toxin) subfamily
Evidence at protein level
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:10491095}.
Additional Detail Fields 7 fields
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Evidence at protein level
Neurotoxin 08 (Shiva) family, 01 (omega toxin) subfamily
Omega-hexatoxin-Hv1e (Omega-HXTX-Hv1e) (Omega-atracotoxin-Hv1e) (Omega-AcTx-Hv1e)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:10491095}.
spider