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Peptide record

TPDB38172

Neurotoxin Toxicity standard
28 amino acids
Basic Information
3D PDB MODEL
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TPDB38172
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 28-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
SNKKDYRKEIVDKHNALSRSVKPTASNM
Physicochemical Analysis
C136H230N44O44S1
CQGFW
K
3217.65
10.47
8
3
8
+4
12.14
-1.332
55.71
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
1490
46.31
9
Residue Composition
number
2
A
2
R
3
N
2
D
0
C
1
E
0
Q
0
G
1
H
1
I
1
L
5
K
1
M
0
F
1
P
4
S
1
T
0
W
1
Y
2
V
Amino Acid Distribution
A: 2 R: 2 N: 3 D: 2 C: 0 E: 1 Q: 0 G: 0 H: 1 I: 1 L: 1 K: 5 M: 1 F: 0 P: 1 S: 4 T: 1 W: 0 Y: 1 V: 2
Chemical Descriptors
28
C136H230N44O44S1
3217.65
10.47
+4
12.14
-1.332
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Blocks contraction of smooth muscle elicited by high potassium-induced depolarization, but does not block caffeine-stimulated contraction. May target voltage-gated calcium channels on smooth muscle (By similarity). {ECO:0000250}.

Target

voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Austrelaps superbus (Lowland copperhead snake) (Hoplocephalus superbus)
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin
Blocks contraction of smooth muscle elicited by high potassium-induced depolarization, but does not block caffeine-stimulated contraction. May target voltage-gated calcium channels on smooth muscle (By similarity)..
Cysteine-rich venom protein asurin-2
snake
CRISP family
Evidence at protein level
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
Additional Detail Fields 7 fields
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Toxin
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin
Evidence at protein level
CRISP family
Cysteine-rich venom protein asurin-2
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
snake