Back to search

Peptide record

TPDB38152

Neurotoxin Toxicity standard
21 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB38152
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 21-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
SLVQFEKMIKEVAGKNGVPWY
Physicochemical Analysis
C113H175N27O30S1
RDCHT
KV
2423.86
9.58
3
2
10
+1
3.63
-0.176
83.33
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
6990
288.38
4
Residue Composition
number
1
A
0
R
1
N
0
D
0
C
2
E
1
Q
2
G
0
H
1
I
1
L
3
K
1
M
1
F
1
P
1
S
0
T
1
W
1
Y
3
V
Amino Acid Distribution
A: 1 R: 0 N: 1 D: 0 C: 0 E: 2 Q: 1 G: 2 H: 0 I: 1 L: 1 K: 3 M: 1 F: 1 P: 1 S: 1 T: 0 W: 1 Y: 1 V: 3
Chemical Descriptors
21
C113H175N27O30S1
2423.86
9.58
+1
3.63
-0.176
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Snake venom phospholipase A2 (PLA2) that induces a conspicuous local myotoxic effect and moderate footpad edema. In vitro, it shows anticoagulant effects and is not cytotoxic on myoblast but is able to lyse myotubes. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. {ECO:0000269|PubMed:19673100}.

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Crotalus durissus cumanensis (South American rattlesnake)
Neurotoxin Presynaptic neurotoxin
Snake venom phospholipase A2 (PLA2) that induces a conspicuous local myotoxic effect and moderate footpad edema. In vitro, it shows anticoagulant effects and is not cytotoxic on myoblast but is able to lyse myotubes.
Phospholipase A2 crotoxin basic chain (CB) (svPLA2) (EC 3.1.1.4) (Cdcum6) (Phosphatidylcholine 2-acylhydrolase)
snake
Phospholipase A2 family, Group II subfamily
Evidence at protein level
Blood coagulation cascade inhibiting toxin Calcium Direct protein sequencing Hemostasis impairing toxin Hydrolase Lipid degradation Lipid metabolism Metal-binding Neurotoxin Presynaptic neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom gland.
Additional Detail Fields 7 fields
Blood coagulation cascade inhibiting toxin Calcium Direct protein sequencing Hemostasis impairing toxin Hydrolase Lipid degradation Lipid metabolism Metal-binding Neurotoxin Presynaptic neurotoxin Secreted Toxin
Neurotoxin Presynaptic neurotoxin
Evidence at protein level
Phospholipase A2 family, Group II subfamily
Phospholipase A2 crotoxin basic chain (CB) (svPLA2) (EC 3.1.1.4) (Cdcum6) (Phosphatidylcholine 2-acylhydrolase)
TISSUE SPECIFICITY: Expressed by the venom gland.
snake