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Peptide record

TPDB38138

Neurotoxin Toxicity standard
35 amino acids
Basic Information
3D PDB MODEL
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TPDB38138
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 35-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
SLIEFGKMITEETNRPVFPYEATIVVCDCGNGNGS
Physicochemical Analysis
C164H256N42O55S3
QHW
EG
3792.27
4.00
2
5
12
-3
8.63
-0.057
72.29
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
1615
42.59
11
Residue Composition
number
1
A
1
R
3
N
1
D
2
C
4
E
0
Q
4
G
0
H
3
I
1
L
1
K
1
M
2
F
2
P
2
S
3
T
0
W
1
Y
3
V
Amino Acid Distribution
A: 1 R: 1 N: 3 D: 1 C: 2 E: 4 Q: 0 G: 4 H: 0 I: 3 L: 1 K: 1 M: 1 F: 2 P: 2 S: 2 T: 3 W: 0 Y: 1 V: 3
Chemical Descriptors
35
C164H256N42O55S3
3792.27
4.00
-3
8.63
-0.057
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Snake venom phospholipase A2 (PLA2) that is the first competitive blocker of nicotinic acetylcholine receptors (nAChRs) (PubMed:21333664). Competes with alpha-bungarotoxin for binding to nAChRs and acetylcholine binding proteins (AChBPs) and blocks acetylcholine-elicited current (PubMed:21333664). PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides (PubMed:21333664). {ECO:0000269|PubMed:21333664}.

Target

nicotinic acetylcholine receptor (nAChR) acetylcholine receptor

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Bitis arietans (African puff adder)
Neurotoxin Postsynaptic neurotoxin
Snake venom phospholipase A2 (PLA2) that is the first competitive blocker of nicotinic acetylcholine receptors (nAChRs) (PubMed:21333664). Competes with alpha-bungarotoxin for binding to nAChRs and acetylcholine binding proteins (AChBPs) and blocks acetylcholine-elicited current (PubMed:21333664).
Phospholipase A2 bitanarin (svPLA2) (EC 3.1.1.4) (Bitis arietans nicotinic acetylcholine receptor inhibitor) (Phosphatidylcholine 2-acylhydrolase)
snake
Phospholipase A2 family, Group II subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Hydrolase Neurotoxin Postsynaptic neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:21333664}.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Hydrolase Neurotoxin Postsynaptic neurotoxin Secreted Toxin
Neurotoxin Postsynaptic neurotoxin
Evidence at protein level
Phospholipase A2 family, Group II subfamily
Phospholipase A2 bitanarin (svPLA2) (EC 3.1.1.4) (Bitis arietans nicotinic acetylcholine receptor inhibitor) (Phosphatidylcholine 2-acylhydrolase)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:21333664}.
snake