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Peptide record

TPDB38133

Neurotoxin Toxicity standard
24 amino acids
Basic Information
3D PDB MODEL
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TPDB38133
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 24-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
SLGGKPDLRPCYPPCHYIPRPKPR
Physicochemical Analysis
C124H195N37O30S2
ANEQMFTWV
P
2748.26
9.98
6
1
5
+4
6.11
-1.096
48.75
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
3105
112.98
5
Residue Composition
number
0
A
3
R
0
N
1
D
2
C
0
E
0
Q
2
G
1
H
1
I
2
L
2
K
0
M
0
F
7
P
1
S
0
T
0
W
2
Y
0
V
Amino Acid Distribution
A: 0 R: 3 N: 0 D: 1 C: 2 E: 0 Q: 0 G: 2 H: 1 I: 1 L: 2 K: 2 M: 0 F: 0 P: 7 S: 1 T: 0 W: 0 Y: 2 V: 0
Chemical Descriptors
24
C124H195N37O30S2
2748.26
9.98
+4
6.11
-1.096
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Waglerin-2 selectively blocks the epsilon subunit of muscle nicotinic acetylcholine receptor (nAChR). Also has effects on rodent ionotropic GABA(A) receptors (GABR), since it potentiates I(GABA) in some neurons and depresses I(GABA) in others. In mice, it elicits tachypnea, ocular proptosis, rapid collapse and spasms, whereas no toxic effects on respiration and blood pressure are observed in rats (By similarity). {ECO:0000250}. FUNCTION: Waglerin-4 selectively blocks the epsilon subunit of muscle nicotinic acetylcholine receptor. It elicits tachypnea, ocular proptosis, rapid collapse and spasms in mice. It causes death by respiratory failure (By similarity). {ECO:0000250}.

Target

nicotinic acetylcholine receptor (nAChR) acetylcholine receptor

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Tropidolaemus wagleri (Wagler's pit viper) (Trimeresurus wagleri)
Neurotoxin Postsynaptic neurotoxin Ion channel impairing toxin
Waglerin-2 selectively blocks the epsilon subunit of muscle nicotinic acetylcholine receptor (nAChR). Also has effects on rodent ionotropic GABA(A) receptors (GABR), since it potentiates I(GABA) in some neurons and depresses I(GABA) in others.
Waglerin-4 (SL-Waglerin-2) [Cleaved into: Waglerin-2 (Lethal peptide II) (Waglerin II)]
snake
Waglerin family
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom gland.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Secreted Toxin
Neurotoxin Postsynaptic neurotoxin Ion channel impairing toxin
Evidence at protein level
Waglerin family
Waglerin-4 (SL-Waglerin-2) [Cleaved into: Waglerin-2 (Lethal peptide II) (Waglerin II)]
TISSUE SPECIFICITY: Expressed by the venom gland.
snake