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Peptide record

TPDB38094

Neurotoxin Toxicity standard
31 amino acids
Basic Information
3D PDB MODEL
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TPDB38094
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 31-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
SKCFSPGTFCGIKPGLCCSVRCFSLFCISFE
Physicochemical Analysis
C150H228N36O40S6
ANDQHMWY
C
3368.04
8.02
3
1
10
+2
-2.23
0.803
59.68
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
375
11.13
12
Residue Composition
number
0
A
1
R
0
N
0
D
6
C
1
E
0
Q
3
G
0
H
2
I
2
L
2
K
0
M
5
F
2
P
5
S
1
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 6 E: 1 Q: 0 G: 3 H: 0 I: 2 L: 2 K: 2 M: 0 F: 5 P: 2 S: 5 T: 1 W: 0 Y: 0 V: 1
Chemical Descriptors
31
C150H228N36O40S6
3368.04
8.02
+2
-2.23
0.803
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Delta-conotoxins bind to site 6 of voltage-gated sodium channels (Nav) and inhibit the inactivation process. Potent paralytic toxin in vertebrate and invertebrate systems. Its binding appears to be voltage-dependent.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus nigropunctatus (Black-spot cone)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Delta-conotoxins bind to site 6 of voltage-gated sodium channels (Nav) and inhibit the inactivation process. Potent paralytic toxin in vertebrate and invertebrate systems.
Delta-conotoxin NgVIA
cone snail
Conotoxin O1 superfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Hydroxylation Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom duct.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Hydroxylation Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Conotoxin O1 superfamily
Delta-conotoxin NgVIA
TISSUE SPECIFICITY: Expressed by the venom duct.
cone snail