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Peptide record

TPDB38090

Neurotoxin Toxicity standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB38090
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 20-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
SIPLPSLNFEQFGNMIQCTI
Physicochemical Analysis
C101H158N24O30S2
ARDHKWYV
I
2252.63
3.29
0
1
8
-1
0.55
0.385
97.50
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
8
Residue Composition
number
0
A
0
R
2
N
0
D
1
C
1
E
2
Q
1
G
0
H
3
I
2
L
0
K
1
M
2
F
2
P
2
S
1
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 2 D: 0 C: 1 E: 1 Q: 2 G: 1 H: 0 I: 3 L: 2 K: 0 M: 1 F: 2 P: 2 S: 2 T: 1 W: 0 Y: 0 V: 0
Chemical Descriptors
20
C101H158N24O30S2
2252.63
3.29
-1
0.55
0.385
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Heterotrimer: Snake venom phospholipase A2 (PLA2) that has presynaptic neurotoxicity. Inhibits nerve-evoked twitch contractions but not responses to cholinergic agonists acetylcholine and carbachol and to depolarizing agonist KCl. Causes a fade in tetanic contractions. Displays a triphasic mode of action with depression, enhancement and blockade of neurotransmission. Does not display myotoxic activity such as changes in baseline muscle tension or inhibition of directly stimulated muscle twitches. All subunits are necessary for maximum toxicity. {ECO:0000269|PubMed:20361942}. FUNCTION: Monomer: the gamma chain has no significant enzymatic activity and is not toxic by itself. {ECO:0000269|PubMed:20361942}.

Target

proton-gated sodium channel / ASIC

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Acanthophis antarcticus (Common death adder)
Neurotoxin Presynaptic neurotoxin
Heterotrimer: Snake venom phospholipase A2 (PLA2) that has presynaptic neurotoxicity. Inhibits nerve-evoked twitch contractions but not responses to cholinergic agonists acetylcholine and carbachol and to depolarizing agonist KCl.
Phospholipase A2 homolog P-elapitoxin-Aa1a gamma chain (P-EPTX-Aa1a gamma chain) (svPLA2 homolog)
snake
Phospholipase A2 family, Group I subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Neurotoxin Presynaptic neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|PubMed:20361942}.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Neurotoxin Presynaptic neurotoxin Secreted Toxin
Neurotoxin Presynaptic neurotoxin
Evidence at protein level
Phospholipase A2 family, Group I subfamily
Phospholipase A2 homolog P-elapitoxin-Aa1a gamma chain (P-EPTX-Aa1a gamma chain) (svPLA2 homolog)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|PubMed:20361942}.
snake