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Peptide record

TPDB38036

Neurotoxin Toxicity standard
14 amino acids
Basic Information
3D PDB MODEL
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TPDB38036
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 14-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
SGCCKHPACGKNRC
Physicochemical Analysis
C55H94N22O17S4
DEQILMFTWYV
C
1463.73
8.73
4
0
1
+3
3.64
-0.743
7.14
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
250
17.08
6
Residue Composition
number
1
A
1
R
1
N
0
D
4
C
0
E
0
Q
2
G
1
H
0
I
0
L
2
K
0
M
0
F
1
P
1
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 1 N: 1 D: 0 C: 4 E: 0 Q: 0 G: 2 H: 1 I: 0 L: 0 K: 2 M: 0 F: 0 P: 1 S: 1 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
14
C55H94N22O17S4
1463.73
8.73
+3
3.64
-0.743
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Alpha-conotoxins bind to the nicotinic acetylcholine receptors (nAChR) and inhibit them. This toxin inhibits rodent (alpha-1-beta-1-delta-epsilon (CHRNA1-CHRNB1-CHRND-CHRNE)> alpha-1-beta-1-delta-gamma (CHRNA1-CHRNB1-CHRNG-CHRND)) and human (alpha-3-beta-2/CHRNA3-CHRNB2) nAChRs heterologously expressed in Xenopus oocytes, but has minimal effect on human alpha-7/CHRNA7 nAChRs. Has no effect on the frequency of responses from the giant fiber (GF)-dorsal longitudinal and GF-tergo trochanteral muscle pathways in the D.melanogaster GF circuit (PubMed:28917942). Has possibly a distinct nAChR binding mode from other alpha-conotoxins, due to a different three residue motif (lacks the Ser-Xaa-Pro motif) (By similarity). {ECO:0000250|UniProtKB:Q2I2R8, ECO:0000269|PubMed:28917942}.

Target

nicotinic acetylcholine receptor (nAChR) acetylcholine receptor

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus purpurascens (Purple cone)
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin Ion channel impairing toxin
Alpha-conotoxins bind to the nicotinic acetylcholine receptors (nAChR) and inhibit them. This toxin inhibits rodent (alpha-1-beta-1-delta-epsilon (CHRNA1-CHRNB1-CHRND-CHRNE)> alpha-1-beta-1-delta-gamma (CHRNA1-CHRNB1-CHRNG-CHRND)) and human (alpha-3-beta-2/CHRNA3-CHRNB2) nAChRs heterologously expressed in Xenopus oocytes, but has minimal effect on human alpha-7/CHRNA7 nAChRs.
Alpha-conotoxin PIC
cone snail
Conotoxin A superfamily
Evidence at protein level
Acetylcholine receptor inhibiting toxin Direct protein sequencing Hydroxylation Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:28917942}.
Additional Detail Fields 7 fields
Acetylcholine receptor inhibiting toxin Direct protein sequencing Hydroxylation Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Secreted Toxin
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin Ion channel impairing toxin
Evidence at protein level
Conotoxin A superfamily
Alpha-conotoxin PIC
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:28917942}.
cone snail