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Peptide record

TPDB38025

Neurotoxin Toxicity standard
32 amino acids
Basic Information
3D PDB MODEL
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TPDB38025
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 32-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
SFCIPFKPCKSDENCCKKFKCKTTGIVKLCRW
Physicochemical Analysis
C166H266N44O42S6
AQHMY
K
3742.57
9.25
8
2
8
+6
5.07
-0.294
45.62
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
5875
156.98
11
Residue Composition
number
0
A
1
R
1
N
1
D
6
C
1
E
0
Q
1
G
0
H
2
I
1
L
7
K
0
M
3
F
2
P
2
S
2
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 1 N: 1 D: 1 C: 6 E: 1 Q: 0 G: 1 H: 0 I: 2 L: 1 K: 7 M: 0 F: 3 P: 2 S: 2 T: 2 W: 1 Y: 0 V: 1
Chemical Descriptors
32
C166H266N44O42S6
3742.57
9.25
+6
5.07
-0.294
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Blocks voltage-gated sodium channels (Nav). Causes tail erection, scratching and a reduction in mobility at a dose level of 1.40 mg/mouse. {ECO:0000269|PubMed:1397265}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Phoneutria nigriventer (Brazilian armed spider) (Ctenus nigriventer)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Blocks voltage-gated sodium channels (Nav). Causes tail erection, scratching and a reduction in mobility at a dose level of 1.40 mg/mouse..
U5-ctenitoxin-Pn1a (U5-CNTX-Pn1a) (Neurotoxin Tx2-9)
spider
Neurotoxin 10 (Hwtx-1) family, 60 (Tx2-9) subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|PubMed:1397265, ECO:0000269|PubMed:16278100}.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Neurotoxin 10 (Hwtx-1) family, 60 (Tx2-9) subfamily
U5-ctenitoxin-Pn1a (U5-CNTX-Pn1a) (Neurotoxin Tx2-9)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|PubMed:1397265, ECO:0000269|PubMed:16278100}.
spider