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Peptide record

TPDB38009

Neurotoxin Toxicity standard
37 amino acids
Basic Information
3D PDB MODEL
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TPDB38009
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 37-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
SDNEFPSGCIEFGKECDLDKGNCQCCRRNGYCSCAVN
Physicochemical Analysis
C162H250N50O59S7
HMTW
C
4066.49
4.37
4
6
7
-2
10.64
-0.670
31.62
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
1865
45.86
16
Residue Composition
number
1
A
2
R
4
N
3
D
7
C
3
E
1
Q
4
G
0
H
1
I
1
L
2
K
0
M
2
F
1
P
3
S
0
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 1 R: 2 N: 4 D: 3 C: 7 E: 3 Q: 1 G: 4 H: 0 I: 1 L: 1 K: 2 M: 0 F: 2 P: 1 S: 3 T: 0 W: 0 Y: 1 V: 1
Chemical Descriptors
37
C162H250N50O59S7
4066.49
4.37
-2
10.64
-0.670
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Omega-agatoxins are antagonists of voltage-gated calcium channels (Cav). They block neuromuscular transmission presynaptically (By similarity). {ECO:0000250}.

Target

voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Ancylometes sp. (South American fishing spider)
Neurotoxin Presynaptic neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Omega-agatoxins are antagonists of voltage-gated calcium channels (Cav). They block neuromuscular transmission presynaptically (By similarity)..
U1-ctenitoxin-Asp1a (U1-CNTX-Asp1a) (Neurotoxin ANC32C7)
spider
Neurotoxin 04 (omega-agtx) family, 03 (type II/III omega-agtx) subfamily
Evidence at protein level
Calcium channel impairing toxin Direct protein sequencing Ion channel impairing toxin Neurotoxin Presynaptic neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|Ref.1}.
Additional Detail Fields 7 fields
Calcium channel impairing toxin Direct protein sequencing Ion channel impairing toxin Neurotoxin Presynaptic neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
Neurotoxin Presynaptic neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Evidence at protein level
Neurotoxin 04 (omega-agtx) family, 03 (type II/III omega-agtx) subfamily
U1-ctenitoxin-Asp1a (U1-CNTX-Asp1a) (Neurotoxin ANC32C7)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|Ref.1}.
spider