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Peptide record

TPDB38006

Neurotoxin Toxicity standard
35 amino acids
Basic Information
3D PDB MODEL
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TPDB38006
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 35-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
SECRWFMGGCDSTLDCCKHLSCKMGLYYCAWDGTF
Physicochemical Analysis
C173H250N44O51S8
NQIPV
C
4018.63
5.32
4
4
12
-1
-1.42
-0.049
36.29
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
14355
357.21
13
Residue Composition
number
1
A
1
R
0
N
3
D
6
C
1
E
0
Q
4
G
1
H
0
I
3
L
2
K
2
M
2
F
0
P
3
S
2
T
2
W
2
Y
0
V
Amino Acid Distribution
A: 1 R: 1 N: 0 D: 3 C: 6 E: 1 Q: 0 G: 4 H: 1 I: 0 L: 3 K: 2 M: 2 F: 2 P: 0 S: 3 T: 2 W: 2 Y: 2 V: 0
Chemical Descriptors
35
C173H250N44O51S8
4018.63
5.32
-1
-1.42
-0.049
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Selectively activates mammalian TRPV1, the capsaicin receptor, a non-selective cation channel expressed by sensory neurons of the pain pathway. Is less potent than VaTx2 and VaTx3. Interacts with distinct regions of the channel than capsaicin, since it only acts on the extracellular face of the channel, and capsaicin binds to the cytosolic side. Also activates avian TRPV1, which is insensitive to capsaicin. Significantly inhibits potassium channels Kv2.1/KCNB1. {ECO:0000269|PubMed:17093448}.

Target

voltage-gated potassium channel (Kv) TRP channel

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Psalmopoeus cambridgei (Trinidad chevron tarantula)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Selectively activates mammalian TRPV1, the capsaicin receptor, a non-selective cation channel expressed by sensory neurons of the pain pathway. Is less potent than VaTx2 and VaTx3.
Tau/kappa-theraphotoxin-Pc1a (Tau/kappa-TRTX-Pc1a) (Vanillotoxin-1) (VaTx1)
spider
Neurotoxin 10 (Hwtx-1) family, 62 (Vatx) subfamily
Evidence at protein level
Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:17093448}.
Additional Detail Fields 7 fields
Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Neurotoxin 10 (Hwtx-1) family, 62 (Vatx) subfamily
Tau/kappa-theraphotoxin-Pc1a (Tau/kappa-TRTX-Pc1a) (Vanillotoxin-1) (VaTx1)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:17093448}.
spider