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Peptide record

TPDB37980

Neurotoxin Toxicity standard
26 amino acids
Basic Information
3D PDB MODEL
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TPDB37980
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 26-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
SCQKWMWLCDEERKCCEDMVCKLWCK
Physicochemical Analysis
C139H215N37O39S8
ANGHIFPTY
C
3284.94
6.19
5
5
8
-0
5.50
-0.538
41.15
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
16875
513.71
8
Residue Composition
number
0
A
1
R
0
N
2
D
6
C
3
E
1
Q
0
G
0
H
0
I
2
L
4
K
2
M
0
F
0
P
1
S
0
T
3
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 2 C: 6 E: 3 Q: 1 G: 0 H: 0 I: 0 L: 2 K: 4 M: 2 F: 0 P: 0 S: 1 T: 0 W: 3 Y: 0 V: 1
Chemical Descriptors
26
C139H215N37O39S8
3284.94
6.19
-0
5.50
-0.538
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Gating-modifier toxin that non-selectively inhibits voltage-gated sodium channel Nav by shifting the threshold for channel activation to more positive potentials. This toxin moderately inhibits human Nav1.2/SCN2A (IC(50)=404 nM), Nav1.5/SCN5A (IC(50)=218 nM) and Nav1.7/SCN9A (IC(50)=333 nM). Inhibition of Nav1.7 is voltage-dependent, with lower inhibition at more positive test pulses. {ECO:0000269|PubMed:26134258}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Phlogius sp. (Tarantula spider)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Gating-modifier toxin that non-selectively inhibits voltage-gated sodium channel Nav by shifting the threshold for channel activation to more positive potentials. This toxin moderately inhibits human Nav1.2/SCN2A (IC(50)=404 nM), Nav1.5/SCN5A (IC(50)=218 nM) and Nav1.7/SCN9A (IC(50)=333 nM).
Mu-theraphotoxin-Phlo2a (Mu-TRTX-Phlo2a)
spider
Neurotoxin 30 (phrixotoxin) family
Evidence at protein level
Cardiotoxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:26134258}.
Additional Detail Fields 7 fields
Cardiotoxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Neurotoxin 30 (phrixotoxin) family
Mu-theraphotoxin-Phlo2a (Mu-TRTX-Phlo2a)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:26134258}.
spider