Back to search

Peptide record

TPDB37970

Neurotoxin Toxicity standard
36 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB37970
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 36-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
SCVGEYGRCRSAYEDCCDGYYCNCSQPPYCLCRNNN
Physicochemical Analysis
C165H242N50O58S8
HIKMFTW
C
4110.52
4.56
3
4
8
-1
5.23
-0.792
21.67
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
7950
193.41
21
Residue Composition
number
1
A
3
R
4
N
2
D
8
C
2
E
1
Q
3
G
0
H
0
I
1
L
0
K
0
M
0
F
2
P
3
S
0
T
0
W
5
Y
1
V
Amino Acid Distribution
A: 1 R: 3 N: 4 D: 2 C: 8 E: 2 Q: 1 G: 3 H: 0 I: 0 L: 1 K: 0 M: 0 F: 0 P: 2 S: 3 T: 0 W: 0 Y: 5 V: 1
Chemical Descriptors
36
C165H242N50O58S8
4110.52
4.56
-1
5.23
-0.792
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Insecticidal neurotoxin that induces irreversible neuromuscular blockade in house crickets (A.domesticus). Modifies presynaptic voltage-gated sodium channels (Nav), causing them to open at the normal resting potential of the nerve. This leads to spontaneous release of neurotransmitter and repetitive action potentials in motor neurons. {ECO:0000269|PubMed:2298738}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Hololena curta (Funnel-web spider) (Agelena curta)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Insecticidal neurotoxin that induces irreversible neuromuscular blockade in house crickets (A.domesticus). Modifies presynaptic voltage-gated sodium channels (Nav), causing them to open at the normal resting potential of the nerve.
Mu-agatoxin-Hc1a (Mu-AGTX-Hc1a) (Curtatoxin-1) (CT-I)
spider
Neurotoxin 07 (Beta/delta-agtx) family, 04 (aga-5) subfamily
Evidence at protein level
Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland.
Additional Detail Fields 7 fields
Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Neurotoxin 07 (Beta/delta-agtx) family, 04 (aga-5) subfamily
Mu-agatoxin-Hc1a (Mu-AGTX-Hc1a) (Curtatoxin-1) (CT-I)
TISSUE SPECIFICITY: Expressed by the venom gland.
spider