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Peptide record

TPDB37968

Neurotoxin Toxicity standard
40 amino acids
Basic Information
3D PDB MODEL
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TPDB37968
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 40-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
SDGRNTAANDKASDLMALRDGCCSNPSCSVNNPDICGGGR
Physicochemical Analysis
C155H257N55O62S5
EQHFWY
NDGS
4043.38
4.47
4
5
9
-1
10.18
-0.672
46.50
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
250
6.18
15
Residue Composition
number
4
A
3
R
5
N
5
D
4
C
0
E
0
Q
5
G
0
H
1
I
2
L
1
K
1
M
0
F
2
P
5
S
1
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 4 R: 3 N: 5 D: 5 C: 4 E: 0 Q: 0 G: 5 H: 0 I: 1 L: 2 K: 1 M: 1 F: 0 P: 2 S: 5 T: 1 W: 0 Y: 0 V: 1
Chemical Descriptors
40
C155H257N55O62S5
4043.38
4.47
-1
10.18
-0.672
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. {ECO:0000250}.

Target

nicotinic acetylcholine receptor (nAChR) acetylcholine receptor

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus quercinus (Oak cone)
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin Ion channel impairing toxin
Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them..
Alpha-conotoxin-like Qc1.4a (Qu-5)
cone snail
Conotoxin A superfamily
Evidence at transcript level
Acetylcholine receptor inhibiting toxin Amidation Disulfide bond Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305}.
Additional Detail Fields 7 fields
Acetylcholine receptor inhibiting toxin Amidation Disulfide bond Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Secreted Toxin
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin Ion channel impairing toxin
Evidence at transcript level
Conotoxin A superfamily
Alpha-conotoxin-like Qc1.4a (Qu-5)
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305}.
cone snail