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Peptide record

TPDB37881

Neurotoxin Toxicity standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB37881
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 16-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
SCCARNPACRHNHPCV
Physicochemical Analysis
C68H110N28O20S4
DEQGILKMFTWY
C
1768.04
8.32
4
0
3
+2
4.18
-0.537
30.63
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
250
14.14
7
Residue Composition
number
2
A
2
R
2
N
0
D
4
C
0
E
0
Q
0
G
2
H
0
I
0
L
0
K
0
M
0
F
2
P
1
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 2 R: 2 N: 2 D: 0 C: 4 E: 0 Q: 0 G: 0 H: 2 I: 0 L: 0 K: 0 M: 0 F: 0 P: 2 S: 1 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
16
C68H110N28O20S4
1768.04
8.32
+2
4.18
-0.537
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This peptide has been experimentally synthesized as AusIA-globular and AusIA-ribbon. Both forms are active on chicken alpha-7/CHRNA7 nAChR with similar potency (micromolar range). {ECO:0000269|PubMed:25194747, ECO:0000269|PubMed:34753970}.

Target

nicotinic acetylcholine receptor (nAChR) acetylcholine receptor

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus australis (Austral cone) (Asprella australis)
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin Ion channel impairing toxin
Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This peptide has been experimentally synthesized as AusIA-globular and AusIA-ribbon.
Alpha-conotoxin AusIA
cone snail
Conotoxin A superfamily
Evidence at protein level
3D-structure Acetylcholine receptor inhibiting toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:25194747}.
Additional Detail Fields 7 fields
3D-structure Acetylcholine receptor inhibiting toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Secreted Toxin
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin Ion channel impairing toxin
Evidence at protein level
Conotoxin A superfamily
Alpha-conotoxin AusIA
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:25194747}.
cone snail