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Peptide record

TPDB37866

Neurotoxin Toxicity modified_plain modified
37 amino acids
Basic Information
3D PDB MODEL
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TPDB37866
Neurotoxin Toxicity
Toxicity and safety peptides
Peptipedia
modified_plain
Yes
A 37-aa modified multi-activity (Neurotoxin and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Modified, details unspecified
Sequence
SCIKIGEDCDGDKDDCQCCRTNGYCSXYXLFGYLKSG
Physicochemical Analysis
C159H243N43O57S6
AHMPWV
C
3861.29
4.24
4
6
8
-2
6.40
-0.508
42.16
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
4845
125.48
15
Residue Composition
number
0
A
1
R
1
N
5
D
6
C
1
E
1
Q
5
G
0
H
2
I
2
L
3
K
0
M
1
F
0
P
3
S
1
T
0
W
3
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 1 D: 5 C: 6 E: 1 Q: 1 G: 5 H: 0 I: 2 L: 2 K: 3 M: 0 F: 1 P: 0 S: 3 T: 1 W: 0 Y: 3 V: 0
Chemical Descriptors
37
C159H243N43O57S6
3861.29
4.24
-2
6.40
-0.508
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Omega-agatoxins are antagonists of voltage-gated calcium channels. This toxin blocks calcium channels in insect central neurons but not at peripheral neuromuscular junctions. In vertebrates, it is broadly active against all high-threshold Cav1/CACNA1 channels and Cav2.2/CACNA1B channels.

Target

voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Agelenopsis aperta (North American funnel-web spider) (Agelenopsis gertschi)
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Omega-agatoxins are antagonists of voltage-gated calcium channels. This toxin blocks calcium channels in insect central neurons but not at peripheral neuromuscular junctions.
Omega-agatoxin-Aa3d (Omega-AGTX-Aa3d) (Omega-agatoxin IIID) (Omega-Aga-IIID) (Omega-agatoxin-3D)
spider
Neurotoxin 04 (omega-agtx) family, 03 (type II/III omega-agtx) subfamily
Evidence at protein level
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland.
Additional Detail Fields 7 fields
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Evidence at protein level
Neurotoxin 04 (omega-agtx) family, 03 (type II/III omega-agtx) subfamily
Omega-agatoxin-Aa3d (Omega-AGTX-Aa3d) (Omega-agatoxin IIID) (Omega-Aga-IIID) (Omega-agatoxin-3D)
TISSUE SPECIFICITY: Expressed by the venom gland.
spider