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Peptide record

TPDB37865

Neurotoxin Toxicity standard
24 amino acids
Basic Information
3D PDB MODEL
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TPDB37865
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 24-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
SCIKHGDFCDGDNDDCQCCRDNGF
Physicochemical Analysis
C103H151N33O41S5
AELMPTWYV
D
2667.83
3.87
3
6
3
-4
7.95
-0.937
16.25
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
250
9.37
9
Residue Composition
number
0
A
1
R
2
N
6
D
5
C
0
E
1
Q
3
G
1
H
1
I
0
L
1
K
0
M
2
F
0
P
1
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 2 D: 6 C: 5 E: 0 Q: 1 G: 3 H: 1 I: 1 L: 0 K: 1 M: 0 F: 2 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
24
C103H151N33O41S5
2667.83
3.87
-4
7.95
-0.937
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Omega-agatoxins are antagonists of voltage-gated calcium channels (Cav). {ECO:0000250}.

Target

voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Ctenus ornatus (Brazilian spider) (Oligoctenus ornatus)
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Omega-agatoxins are antagonists of voltage-gated calcium channels (Cav)..
U4-ctenitoxin-Co1b (U4-CNTX-Co1b) (Neurotoxin Oc F29-9-1)
spider
Neurotoxin 04 (omega-agtx) family, 03 (type II/III omega-agtx) subfamily
Evidence at protein level
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|Ref.1}.
Additional Detail Fields 7 fields
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Evidence at protein level
Neurotoxin 04 (omega-agtx) family, 03 (type II/III omega-agtx) subfamily
U4-ctenitoxin-Co1b (U4-CNTX-Co1b) (Neurotoxin Oc F29-9-1)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|Ref.1}.
spider