Back to search

Peptide record

TPDB37859

Neurotoxin Toxicity standard
76 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB37859
Neurotoxin Toxicity
Toxicity and safety peptides
Peptipedia
standard
No
A 76-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
SCIDIGGDCDGEKDDCQCCRRNGYCSCYSLFGYLKSGCKCVVGTSAEFQGICRRKARQCYNSDPDKCESHNKPKRR
Physicochemical Analysis
C347H552N112O115S12
MW
C
8517.60
8.02
15
10
15
+4
22.11
-0.884
35.92
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
6710
78.78
30
Residue Composition
number
2
A
7
R
3
N
7
D
12
C
3
E
3
Q
8
G
1
H
3
I
2
L
7
K
0
M
2
F
2
P
7
S
1
T
0
W
4
Y
2
V
Amino Acid Distribution
A: 2 R: 7 N: 3 D: 7 C: 12 E: 3 Q: 3 G: 8 H: 1 I: 3 L: 2 K: 7 M: 0 F: 2 P: 2 S: 7 T: 1 W: 0 Y: 4 V: 2
Chemical Descriptors
76
C347H552N112O115S12
8517.60
8.02
+4
22.11
-0.884
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Omega-agatoxin are antagonist of voltage-gated calcium channels. They block insect neuromuscular transmission presynaptically. Potent blocker of N- (Cav2.2/CACNA1B) and L-type (Cav1/CACNA1) calcium channels.

Target

voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Agelenopsis aperta (North American funnel-web spider) (Agelenopsis gertschi)
Neurotoxin Presynaptic neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Omega-agatoxin are antagonist of voltage-gated calcium channels. They block insect neuromuscular transmission presynaptically.
Omega-agatoxin-Aa3a (Omega-AGTX-Aa3a) (Omega-agatoxin IIIA) (Omega-Aga-IIIA) (Omega-agatoxin-3A)
spider
Neurotoxin 04 (omega-agtx) family, 03 (type II/III omega-agtx) subfamily
Evidence at protein level
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Presynaptic neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland.
Additional Detail Fields 7 fields
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Presynaptic neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
Neurotoxin Presynaptic neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Evidence at protein level
Neurotoxin 04 (omega-agtx) family, 03 (type II/III omega-agtx) subfamily
Omega-agatoxin-Aa3a (Omega-AGTX-Aa3a) (Omega-agatoxin IIIA) (Omega-Aga-IIIA) (Omega-agatoxin-3A)
TISSUE SPECIFICITY: Expressed by the venom gland.
spider