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Peptide record

TPDB37856

Neurotoxin Toxicity standard
76 amino acids
Basic Information
3D PDB MODEL
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TPDB37856
Neurotoxin Toxicity
Toxicity and safety peptides
Peptipedia
standard
No
A 76-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
SCIDFGGDCDGEKDDCQCCRSNGYCSCYNLFGYLKSGCKCEVGTSAEFRRICRRKAKQCYNSDPDKCVSVYKPKRR
Physicochemical Analysis
C357H562N110O115S12
HMW
C
8619.78
8.16
15
10
17
+4
19.86
-0.826
34.61
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
8200
95.13
30
Residue Composition
number
2
A
7
R
3
N
7
D
12
C
3
E
2
Q
7
G
0
H
2
I
2
L
8
K
0
M
3
F
2
P
7
S
1
T
0
W
5
Y
3
V
Amino Acid Distribution
A: 2 R: 7 N: 3 D: 7 C: 12 E: 3 Q: 2 G: 7 H: 0 I: 2 L: 2 K: 8 M: 0 F: 3 P: 2 S: 7 T: 1 W: 0 Y: 5 V: 3
Chemical Descriptors
76
C357H562N110O115S12
8619.78
8.16
+4
19.86
-0.826
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Omega-agatoxins are antagonists of voltage-gated calcium channels. This toxin blocks calcium channels in insect central neurons but not at peripheral neuromuscular junctions. In vertebrates, it is broadly active against all high-threshold Cav1/CACNA1 channels and Cav2.2/CACNA1B channels. {ECO:0000269|PubMed:8172884}.

Target

voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Agelenopsis aperta (North American funnel-web spider) (Agelenopsis gertschi)
Neurotoxin Presynaptic neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Omega-agatoxins are antagonists of voltage-gated calcium channels. This toxin blocks calcium channels in insect central neurons but not at peripheral neuromuscular junctions.
Omega-agatoxin-Aa3b (Omega-AGTX-Aa3b) (Omega-agatoxin IIIB) (Omega-Aga-IIIB) (Omega-agatoxin-3B)
spider
Neurotoxin 04 (omega-agtx) family, 03 (type II/III omega-agtx) subfamily
Evidence at protein level
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Presynaptic neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland.
Additional Detail Fields 7 fields
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Presynaptic neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
Neurotoxin Presynaptic neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Evidence at protein level
Neurotoxin 04 (omega-agtx) family, 03 (type II/III omega-agtx) subfamily
Omega-agatoxin-Aa3b (Omega-AGTX-Aa3b) (Omega-agatoxin IIIB) (Omega-Aga-IIIB) (Omega-agatoxin-3B)
TISSUE SPECIFICITY: Expressed by the venom gland.
spider