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Peptide record

TPDB37745

Neurotoxin Toxicity standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB37745
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 15-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
RQRHPDCDKPPDTGN
Physicochemical Analysis
C69H110N26O25S1
AEILMFSWYV
DP
1735.85
7.16
4
3
0
+0
9.52
-2.467
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
4
Residue Composition
number
0
A
2
R
1
N
3
D
1
C
0
E
1
Q
1
G
1
H
0
I
0
L
1
K
0
M
0
F
3
P
0
S
1
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 2 N: 1 D: 3 C: 1 E: 0 Q: 1 G: 1 H: 1 I: 0 L: 0 K: 1 M: 0 F: 0 P: 3 S: 0 T: 1 W: 0 Y: 0 V: 0
Chemical Descriptors
15
C69H110N26O25S1
1735.85
7.16
+0
9.52
-2.467
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Neurotoxin T1-2 is a presynaptic neurotoxin of the venom that exhibits indirect hemolytic activity against human erythrocytes. The B chain is homologous to venom basic protease inhibitors but has no protease inhibitor activity and is non-toxic. {ECO:0000269|PubMed:14769867}.

Target

proton-gated sodium channel / ASIC

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Bungarus candidus (Malayan krait)
Neurotoxin Presynaptic neurotoxin
Neurotoxin T1-2 is a presynaptic neurotoxin of the venom that exhibits indirect hemolytic activity against human erythrocytes. The B chain is homologous to venom basic protease inhibitors but has no protease inhibitor activity and is non-toxic..
Kunitz-type serine protease inhibitor homolog T1-2 B chain (Neurotoxin T1-2 B chain)
snake
Venom Kunitz-type family
Evidence at protein level
Direct protein sequencing Disulfide bond Neurotoxin Presynaptic neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|PubMed:14769867}.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Neurotoxin Presynaptic neurotoxin Secreted Toxin
Neurotoxin Presynaptic neurotoxin
Evidence at protein level
Venom Kunitz-type family
Kunitz-type serine protease inhibitor homolog T1-2 B chain (Neurotoxin T1-2 B chain)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|PubMed:14769867}.
snake