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Peptide record

TPDB37717

[Thr6]-bradykinin Neuropeptide Neurotoxin Toxicity standard

9 amino acids

3D PDB MODEL

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TPDB ID TPDB37717

Peptide_Name

[Thr6]-bradykinin

Activity

Neuropeptide Neurotoxin Toxicity

Activity_category_statistics

Toxicity and safety peptides Neuroactive peptides

Database_Source

Peptipedia NTxPred2 ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 9-aa standard natural multi-activity (Neuropeptide, Neurotoxin, and Toxicity) peptide sequence curated from Peptipedia, NTxPred2, and ToxinPred 3.0, with an available 3D structural model.

Sequence

RPPGFTPFR

FASTA

>TPDB37717|Neuropeptide;Neurotoxin;Toxicity|length=9
RPPGFTPFR

Formula C51H75N15O11

Absent Amino Acids ANDCEQHILKMSWYV

Common Amino Acids P

Mass 1074.25

PI 12.40

Basic Residues 2

Acidic Residues 0

Hydrophobic Residues 2

Net Charge +2

Boman Index 0.86

Hydrophobicity -1.033

Aliphatic Index 0.00

Half Life

Mammalian: 1 hour Yeast: 2 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 1

number

Amino Acid Distribution

A: 0 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 0 M: 0 F: 2 P: 3 S: 0 T: 1 W: 0 Y: 0 V: 0

Length

Formula

C51H75N15O11

Mass

1074.25

12.40

Net Charge

Boman Index

0.86

Hydrophobicity

-1.033

Evidence 1 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Megascolia flavifrons

Family Bradykinin-related peptide

Evidence 2 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Polybia occidentalis

Family Bradykinin-related peptide

Evidence 3 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Phyllomedusa sauvagei

Family Bradykinin-related peptide

Evidence 4 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Bombina orientalis

Family Bradykinin-related peptide

Evidence 5 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Pelophylax ridibundus

Family Bradykinin-related peptide

Evidence 6 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Bombina variegata

Family Bradykinin-related peptide

Evidence 7 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Phasmahyla jandaia

Family Bradykinin-related peptide

Evidence 8 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Trachemys scripta

Family Bradykinin-related peptide

Evidence 9 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Pithecopus hypochondrialis

Family Bradykinin-related peptide

Evidence 10 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Cyphononyx dorsalis

Family Bradykinin-related peptide

Evidence 11 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Agalychnis callidryas

Family Bradykinin-related peptide

Evidence 12 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Agalychnis dacnicolor

Family Bradykinin-related peptide

Evidence 13 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Pithecopus azureus

Family Bradykinin-related peptide

Evidence 14 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Physalaemus nattereri

Family Bradykinin-related peptide

Evidence 15 Activity

Activity

Detail Source Activity Neurotoxin

Function Text

FUNCTION: When injected into the rat central nervous system, exhibits antinociceptive effects such as increasing hot plate and tail flick withdrawal latencies in a dose- and time-dependent fashion (PubMed:17533426). Likely to act on the bradykinin receptor B2 (BDKRB2) (PubMed:17533426). The greatest antinociceptive effects occurs 30 minutes after injection in hot plate (ED(50)=6.82 nM) and tail flick tests (ED(50)=2.94 nM) (PubMed:17533426). {ECO:0000269|PubMed:17533426}.

Source & Reference

Database Source NA

Source UniProtKB/Swiss-Prot Tox-Prot

Other

Organism Source Polybia occidentalis (Paper wasp)

Neurotoxin Type Neurotoxin Bradykinin receptor impairing toxin G-protein coupled receptor impairing toxin

Mechanism

When injected into the rat central nervous system, exhibits antinociceptive effects such as increasing hot plate and tail flick withdrawal latencies in a dose- and time-dependent fashion (PubMed:17533426). Likely to act on the bradykinin receptor B2 (BDKRB2) (PubMed:17533426).

Protein Name Thr6-bradykinin (Bradykinin-related peptide)

Venom Taxon Group insect

Protein Family Bradykinin-related peptide family

Protein Existence Evidence at protein level

Keywords Bradykinin receptor impairing toxin Direct protein sequencing G-protein coupled receptor impairing toxin Neurotoxin Secreted Toxin

Tissue Specificity TISSUE SPECIFICITY: Expressed in the venom reservoir. {ECO:0000305|PubMed:17533426, ECO:0000305|Ref.2}.

Family

Bradykinin-related peptide

Keywords

Bradykinin receptor impairing toxin Direct protein sequencing G-protein coupled receptor impairing toxin Neurotoxin Secreted Toxin

Neurotoxin_Type

Neurotoxin Bradykinin receptor impairing toxin G-protein coupled receptor impairing toxin

Protein_Existence

Evidence at protein level

Protein_Family

Bradykinin-related peptide family

Protein_Name

Thr6-bradykinin (Bradykinin-related peptide)

Tissue_Specificity

TISSUE SPECIFICITY: Expressed in the venom reservoir. {ECO:0000305|PubMed:17533426, ECO:0000305|Ref.2}.

Venom_Taxon_Group

insect