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Peptide record

TPDB37676

Neurotoxin Toxicity standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB37676
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 15-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
RKRHPDCDKAADTRI
Physicochemical Analysis
C72H124N28O23S1
NEQGLMFSWYV
RD
1782.01
9.90
6
3
3
+2
8.76
-1.780
39.33
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
2
Residue Composition
number
2
A
3
R
0
N
3
D
1
C
0
E
0
Q
0
G
1
H
1
I
0
L
2
K
0
M
0
F
1
P
0
S
1
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 3 N: 0 D: 3 C: 1 E: 0 Q: 0 G: 0 H: 1 I: 1 L: 0 K: 2 M: 0 F: 0 P: 1 S: 0 T: 1 W: 0 Y: 0 V: 0
Chemical Descriptors
15
C72H124N28O23S1
1782.01
9.90
+2
8.76
-1.780
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Neurotoxin T1-1 is a presynaptic neurotoxin of the venom that exhibits indirect hemolytic activity against human erythrocytes. The B chain is homologous to venom basic protease inhibitors but has no protease inhibitor activity and is non-toxic. {ECO:0000269|PubMed:14769867}.

Target

proton-gated sodium channel / ASIC

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Bungarus candidus (Malayan krait)
Neurotoxin Presynaptic neurotoxin
Neurotoxin T1-1 is a presynaptic neurotoxin of the venom that exhibits indirect hemolytic activity against human erythrocytes. The B chain is homologous to venom basic protease inhibitors but has no protease inhibitor activity and is non-toxic..
Kunitz-type serine protease inhibitor homolog T1-1 B chain (Neurotoxin T1-1 B chain)
snake
Venom Kunitz-type family
Evidence at protein level
Direct protein sequencing Disulfide bond Neurotoxin Presynaptic neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|PubMed:14769867}.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Neurotoxin Presynaptic neurotoxin Secreted Toxin
Neurotoxin Presynaptic neurotoxin
Evidence at protein level
Venom Kunitz-type family
Kunitz-type serine protease inhibitor homolog T1-1 B chain (Neurotoxin T1-1 B chain)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|PubMed:14769867}.
snake