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Peptide record

TPDB37671

Neurotoxin Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB37671
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 13-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
RIKIGLFDQLSRL
Physicochemical Analysis
C71H123N21O18
ANCEHMPTWYV
L
1558.89
11.32
3
1
6
+2
1.13
0.162
150.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
2
Residue Composition
number
0
A
2
R
0
N
1
D
0
C
0
E
1
Q
1
G
0
H
2
I
3
L
1
K
0
M
1
F
0
P
1
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 1 C: 0 E: 0 Q: 1 G: 1 H: 0 I: 2 L: 3 K: 1 M: 0 F: 1 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
13
C71H123N21O18
1558.89
11.32
+2
1.13
0.162
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Inhibits sodium channel (Nav) inactivation. Shows two types of inhibitory activities on channels. Inhibition of insect DmNav1/para and hNav1.6/SCN8A shows a large increase in the steady-state current component without any increase in the slow component, whereas inhibition of hNav1.1/SCN1A, hNav1.2/SCN2A, hNav1.3/SCN3A and hNav1.7/SCN9A shows a large increase in the slow component with only a small steady-state component (PubMed:20059541). Is 5-fold more potent than alpha-PMTX for inducing repetitive action potentials in lobster neuromuscular junctions. {ECO:0000269|PubMed:11755223, ECO:0000269|PubMed:12123851, ECO:0000269|PubMed:14715935, ECO:0000269|PubMed:20059541}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Batozonellus maculifrons (Solitary wasp)
Neurotoxin Presynaptic neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Inhibits sodium channel (Nav) inactivation. Shows two types of inhibitory activities on channels.
Beta-pompilidotoxin (Beta-PMTX)
insect
Evidence at protein level
Amidation Direct protein sequencing Ion channel impairing toxin Neurotoxin Presynaptic neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
Additional Detail Fields 6 fields
Amidation Direct protein sequencing Ion channel impairing toxin Neurotoxin Presynaptic neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Presynaptic neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Beta-pompilidotoxin (Beta-PMTX)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
insect