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Peptide record

TPDB37634

Neurotoxin Toxicity standard
64 amino acids
Basic Information
3D PDB MODEL
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TPDB37634
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 64-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
RICLNQQQSTPEDQPTNGQCYIKTDCQNKTWNTHRGSRTDRGCGCPKVKPGINLRCCKTDKCNE
Physicochemical Analysis
C295H484N100O99S8
AMF
C
7272.18
8.52
12
6
8
+5
22.31
-1.311
35.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
7490
103.00
30
Residue Composition
number
0
A
5
R
6
N
4
D
8
C
2
E
6
Q
5
G
1
H
3
I
2
L
6
K
0
M
0
F
4
P
2
S
7
T
1
W
1
Y
1
V
Amino Acid Distribution
A: 0 R: 5 N: 6 D: 4 C: 8 E: 2 Q: 6 G: 5 H: 1 I: 3 L: 2 K: 6 M: 0 F: 0 P: 4 S: 2 T: 7 W: 1 Y: 1 V: 1
Chemical Descriptors
64
C295H484N100O99S8
7272.18
8.52
+5
22.31
-1.311
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Binds to muscle nicotinic acetylcholine receptor (nAChR) and inhibit acetylcholine from binding to the receptor, thereby impairing neuromuscular transmission. {ECO:0000250|UniProtKB:P60775}.

Target

nicotinic acetylcholine receptor (nAChR) acetylcholine receptor

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Bungarus fasciatus (Banded krait) (Pseudoboa fasciata)
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin Ion channel impairing toxin
Binds to muscle nicotinic acetylcholine receptor (nAChR) and inhibit acetylcholine from binding to the receptor, thereby impairing neuromuscular transmission..
Short neurotoxin 1 (Toxin V-II-1)
snake
Three-finger toxin family, Short-chain subfamily, Type I alpha-neurotoxin sub-subfamily
Evidence at protein level
Acetylcholine receptor inhibiting toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
Additional Detail Fields 7 fields
Acetylcholine receptor inhibiting toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Secreted Toxin
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin Ion channel impairing toxin
Evidence at protein level
Three-finger toxin family, Short-chain subfamily, Type I alpha-neurotoxin sub-subfamily
Short neurotoxin 1 (Toxin V-II-1)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
snake