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Peptide record

TPDB37623

Neurotoxin Toxicity standard
43 amino acids
Basic Information
3D PDB MODEL
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TPDB37623
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 43-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
RGVCSTPEGSCVHNGCICQNAPCCHPSGCNWANVCPGYLWDKN
Physicochemical Analysis
C189H283N59O59S8
MF
C
4582.17
6.84
4
2
10
-0
4.47
-0.300
43.02
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
12990
283.49
19
Residue Composition
number
2
A
1
R
5
N
1
D
8
C
1
E
1
Q
5
G
2
H
1
I
1
L
1
K
0
M
0
F
4
P
3
S
1
T
2
W
1
Y
3
V
Amino Acid Distribution
A: 2 R: 1 N: 5 D: 1 C: 8 E: 1 Q: 1 G: 5 H: 2 I: 1 L: 1 K: 1 M: 0 F: 0 P: 4 S: 3 T: 1 W: 2 Y: 1 V: 3
Chemical Descriptors
43
C189H283N59O59S8
4582.17
6.84
-0
4.47
-0.300
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Mu-conotoxins block voltage-gated sodium channels. This toxin reversibly blocks voltage-gated sodium channel in cephalopods, with no alteration in the voltage dependence of sodium conductance or on the kinetics of inactivation (By similarity). {ECO:0000250}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Californiconus californicus (California cone) (Conus californicus)
Neurotoxin Ion channel impairing toxin
Mu-conotoxins block voltage-gated sodium channels. This toxin reversibly blocks voltage-gated sodium channel in cephalopods, with no alteration in the voltage dependence of sodium conductance or on the kinetics of inactivation (By similarity)..
Mu-conotoxin-like Cal 12.2c (Conotoxin CalTx 12.2.1C)
cone snail
Evidence at transcript level
Bromination Disulfide bond Hydroxylation Ion channel impairing toxin Neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom duct.
Additional Detail Fields 6 fields
Bromination Disulfide bond Hydroxylation Ion channel impairing toxin Neurotoxin Secreted Toxin
Neurotoxin Ion channel impairing toxin
Evidence at transcript level
Mu-conotoxin-like Cal 12.2c (Conotoxin CalTx 12.2.1C)
TISSUE SPECIFICITY: Expressed by the venom duct.
cone snail