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Peptide record

TPDB37618

Antiviral Neurotoxin Toxicity standard
22 amino acids
Basic Information
3D PDB MODEL
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TPDB37618
Antiviral Neurotoxin Toxicity
Anti-infective peptides Toxicity and safety peptides
AVPpred-BWR NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 22-aa standard natural multi-activity (Antiviral, Neurotoxin, and Toxicity) peptide sequence curated from AVPpred-BWR, NTxPred2, Peptipedia, and other sources, with an available 3D structural model.
Sequence
RHGCCKGPKGCSSRECRPQHCC
Physicochemical Analysis
C92H154N38O28S6
ANDILMFTWYV
C
2432.83
8.60
7
1
0
+4
8.68
-1.168
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
375
15.41
9
Residue Composition
number
0
A
3
R
0
N
0
D
6
C
1
E
1
Q
3
G
2
H
0
I
0
L
2
K
0
M
0
F
2
P
2
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 3 N: 0 D: 0 C: 6 E: 1 Q: 1 G: 3 H: 2 I: 0 L: 0 K: 2 M: 0 F: 0 P: 2 S: 2 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
22
C92H154N38O28S6
2432.83
8.60
+4
8.68
-1.168
Evidence Records 2 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Mu-conotoxins block voltage-gated sodium channels. This synthetic peptide reversibly inhibits the brain sodium channel rNav1.2/SCN2A (IC(50) is 40 nM) and the skeletal muscle sodium channel rNav1.4/SCN4A (IC(50) is 9 nM). {ECO:0000269|PubMed:17142296}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus striatus (Striated cone)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Mu-conotoxins block voltage-gated sodium channels. This synthetic peptide reversibly inhibits the brain sodium channel rNav1.2/SCN2A (IC(50) is 40 nM) and the skeletal muscle sodium channel rNav1.4/SCN4A (IC(50) is 9 nM)..
Mu-conotoxin SIIIC (Mu-conotoxin TIIIA-like)
cone snail
Conotoxin M superfamily
Evidence at protein level
Amidation Direct protein sequencing Disulfide bond Hydroxylation Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:17142296}.
Evidence 2 Activity

Activity

Neurotoxin
FUNCTION: Mu-conotoxins block voltage-gated sodium channels (Nav). This synthetic toxin reversibly and potently blocks rNav1.4/SCN4A (IC(50) is 9 nM) and rNav1.2/SCN2A (IC(50) is 40 nM). It also moderately blocks rNav1.1/SCN1A, rNav1.3/SCN3A, and rNav1.6/SCN8A. The block of SCN1A and SCN2A is modified when beta-subunits are coexpressed with alpha subunits. Hence, blocks of channels containing beta-1 and beta-3 subunits are more potent (compared to channels without beta subunits), whereas blocks of channels containing beta-2 and beta-4 subunits are less potent (compared to channels without beta subunits). {ECO:0000269|PubMed:21652775, ECO:0000269|PubMed:22229737, ECO:0000269|PubMed:23146020}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus tulipa (Fish-hunting cone snail) (Tulip cone)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Mu-conotoxins block voltage-gated sodium channels (Nav). This synthetic toxin reversibly and potently blocks rNav1.4/SCN4A (IC(50) is 9 nM) and rNav1.2/SCN2A (IC(50) is 40 nM).
Mu-conotoxin TIIIA
cone snail
Conotoxin M superfamily
Evidence at protein level
Amidation Disulfide bond Hydroxylation Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom duct.
Additional Detail Fields 7 fields
Amidation Direct protein sequencing Disulfide bond Hydroxylation Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Conotoxin M superfamily
Mu-conotoxin SIIIC (Mu-conotoxin TIIIA-like) Mu-conotoxin TIIIA
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:17142296}. TISSUE SPECIFICITY: Expressed by the venom duct.
cone snail