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Peptide record

TPDB37606

Arginylglycylaspartic acid RGD RGD mimetic RGD peptide RGDYK Cell-penetrating Peptides Toxicity Tumor-homing Peptides standard
3 amino acids
Basic Information
3D PDB MODEL
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TPDB37606
Arginylglycylaspartic acid RGD RGD mimetic RGD peptide RGDYK
Cell-penetrating Peptides Toxicity Tumor-homing Peptides
Cancer-related peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
CPPsite3.0 Peptipedia TumorHoPe2.0
standard
No
A 3-aa standard natural multi-activity (Cell-penetrating Peptides, Toxicity, and Tumor-homing Peptides) peptide sequence curated from CPPsite3.0, Peptipedia, and TumorHoPe2.0, with an available 3D structural model.
Sequence
RGD
Physicochemical Analysis
C12H22N6O6
ANCEQHILKMFPSTWYV
RDG
346.34
6.78
1
1
0
-0
2.05
-2.800
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
1
R
0
N
1
D
0
C
0
E
0
Q
1
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
3
C12H22N6O6
346.34
6.78
-0
2.05
-2.800
RGD
Evidence Records 7 records
Evidence 1 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Homing
Lung cancer, Breast cancer, Liver cancer, Melanoma, stomach cancer, Pancreatic cancer, Colorectal cancer, Ovarian cancer, Renal cell carcinoma, Prostate cancer, Brain tumor

Source & Reference

TumorHoPe2.0
TumorHoPe2
Noxa-derived, cell death-inducing peptide eMTD
2022
US 11248024 B2
US 11248024 B2

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
Sp2/0, CHO (Chinese hamster ovary) K1, CHO DG44, PER.C6, W138, BHK, COS7, 293, HepG2, Huh7, 3T3, RIN, MDCK cell line
6-week-old BalB/C mice
Synthetic
necrosis-inducing peptide, Fluorescein (FAM)
Evidence 2 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Targeting
Breast cancer
Integrin αvβ3

Source & Reference

TumorHoPe2.0
TumorHoPe2
Preparation and preliminary evaluation of hepatitis B core antigen virus like nanoparticles loaded with indocyanine green
2020
Yunlong Wang et al. Ann Transl Med. 2020 Dec 8(24):1661.

Other

4T1 murine breast cancer cell line
BALB/c female mice
Synthetic
Indocyanine green (ICG), HBc virus-like particles (VLPs)
Evidence 3 Activity

Activity

Tumor-homing Peptides

Target

Endothelial cell
Targeting
Metastatic Breast cancer
αvβ3 integrin

Source & Reference

TumorHoPe2.0
TumorHoPe2
Rational design of multimodal therapeutic nanosystems for effective inhibition of tumor growth and metastasis
2018
Feihu Wang et al. Acta Biomater. 2018 Sep 1. 77(240-254).

Other

MDA-MB-435 cancer cell line, human microvascular endothe lial cells (HMVEC), mouse embryonic fibroblasts NIH3T3
Female BALB/c nude mice
Synthetic
doxorubicin(DOX), p65-shRNA
Evidence 4 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Homing
Colon cancer
integrin receptors, GGT (gamma-glutamyl transpeptidase)

Source & Reference

TumorHoPe2.0
TumorHoPe2
Targeting death receptors for drug-resistant cancer therapy: Codelivery of pTRAIL and monensin using dual-targeting and stimuli-responsive self-assembling nanocomposites
2018
Fan Xu et al. Biomaterials. 2018 Mar:158:56-73.

Other

HCT8/ADR colon cancer cells
female BALB/c nude mice (3−4 weeks)
Polyethyleneimine (PEI), β-Cyclodextrin (β-CD), Monensin, TRAIL DNA
Evidence 5 Activity

Activity

Tumor-homing Peptides

Target

Homing
aVb3 and aVb5 integrin

Source & Reference

TumorHoPe2.0
TumorHoPe2
Camptothecins in tumor homing via an RGD sequence mimetic
2012
Domenico Alloatti et al. Bioorg Med Chem Lett. 2012 Oct 15 22(20):6509-12.

Other

human ovarian carcinoma A2780, human prostate cancer PC3
rat plasma
Synthetic
camptothecins
Evidence 6 Activity

Activity

Tumor-homing Peptides

Target

clonogenic cell, tumor stem cell, Tumor cell
Homing
Glioma (Brain tumors), Liver cancer, Spleen cancer

Source & Reference

TumorHoPe2.0
TumorHoPe2
Solid tumor penetration by integrin-mediated pegylated poly(trimethylene carbonate) nanoparticles loaded with paclitaxel
2012
Xinyi Jiang et al. Biomaterials. 2013 Feb 34(6):1739-46.

Other

U87MG cells
Female BALB/c mice (20 2 g)
Synthetic
PEG-PTMC nanoparticle
Cyclic
Evidence 7 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Targeting
Bladder cancer
Integrin vβ3, Neuropilin-1

Source & Reference

TumorHoPe2.0
TumorHoPe2
RGD peptide modified platinum nanozyme Co-loaded glutathione-responsive prodrug nanoparticles for enhanced chemo-photodynamic bladder cancer therapy
2023
Hao Y at al. Biomaterials. 2023 Feb:293:121975.

Other

T24
Balb/c nude mice bearing T24 subcutaneous tumor model
Synthetic
Paclitaxel (PTX), 2-(1-hexyloxyethyl)-2-devinyl pyropheophorbide-a (HPPH), platinum nanozyme (PtNP), glutathione (GSH)
Additional Detail Fields 3 fields
necrosis-inducing peptide, Fluorescein (FAM) Indocyanine green (ICG), HBc virus-like particles (VLPs) doxorubicin(DOX), p65-shRNA Polyethyleneimine (PEI), β-Cyclodextrin (β-CD), Monensin, TRAIL DNA camptothecins PEG-PTMC nanoparticle Paclitaxel (PTX), 2-(1-hexyloxyethyl)-2-devinyl pyropheophorbide-a (HPPH), platinum nanozyme (PtNP), glutathione (GSH)
Sp2/0, CHO (Chinese hamster ovary) K1, CHO DG44, PER.C6, W138, BHK, COS7, 293, HepG2, Huh7, 3T3, RIN, MDCK cell line 4T1 murine breast cancer cell line MDA-MB-435 cancer cell line, human microvascular endothe lial cells (HMVEC), mouse embryonic fibroblasts NIH3T3 HCT8/ADR colon cancer cells human ovarian carcinoma A2780, human prostate cancer PC3 U87MG cells T24
6-week-old BalB/C mice BALB/c female mice Female BALB/c nude mice female BALB/c nude mice (3−4 weeks) rat plasma Female BALB/c mice (20 2 g) Balb/c nude mice bearing T24 subcutaneous tumor model